Actinotignum schaalii infection - a case series from a tertiary hospital in Greece.

IF 1.7 Q3 INFECTIOUS DISEASES
GERMS Pub Date : 2022-09-01 DOI:10.18683/germs.2022.1343
Petros Ioannou, Stamatis Karakonstantis, Emmanuil Tavlas, Nikolaos Kontopodis, Sofia Maraki, George Chamilos, Diamantis P Kofteridis
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Abstract

Introduction: Actinotignum schaalii is a small Gram-positive facultative anaerobic coccoid rod that was reclassified in 1997 from the genus Actinomyces and is difficult to culture with usual microbiological techniques, as it is slowly growing. A. schaalii is an emerging human pathogen that is most commonly implicated in urinary tract infections (UTIs), but has also been isolated less frequently from abscesses of various sites (such as the skin, the genitourinary tract, surgical sites or intraabdominal).

Methods: All cases where A. schaalii was identified during a 6-year period (January 2016 - January 2022) in the University Hospital of Heraklion were reviewed.

Results: A. schaalii was isolated in 11 cultures from 10 patients. The site of infection was skin and soft tissue in nine out of eleven cultures (81.8%) and the bone was the site of infection in two patients (18.2%). Most cultures were polymicrobial. The median age of patients was 55.5 years (interquartile range 34-63 years), and 80% (n=8) were male. A. schaalii was susceptible to beta-lactams, quinolones and vancomycin, but resistant to clindamycin, erythromycin and metronidazole. Moreover, two cases of diabetic patients diagnosed with polymicrobial diabetic foot osteomyelitis from this organism are presented in detail. Both patients were successfully managed with targeted antimicrobial treatment and prompt surgical management.

Conclusions: A. schaalii is an emerging pathogen that is likely under-reported due to difficulties in isolation and identification. Herein two cases of diabetic foot osteomyelitis are also presented in detail, successfully managed with targeted antimicrobial therapy and surgical debridement.

沙利放线菌感染——来自希腊某三级医院的系列病例。
沙利放线菌(Actinotignum schaalii)是一种小型革兰氏阳性兼性厌氧球虫棒状菌,于1997年从放线菌属中重新分类,由于其生长缓慢,通常的微生物学技术难以培养。沙蚤是一种新出现的人类病原体,最常与尿路感染(uti)有关,但也很少从不同部位的脓肿(如皮肤、泌尿生殖道、手术部位或腹腔内)中分离出来。方法:回顾性分析伊拉克利翁大学医院2016年1月- 2022年1月6年间收治的所有沙利拟虫病例。结果:从10例患者的11个培养物中分离到沙氏单胞菌。11例患者中有9例感染部位为皮肤和软组织(81.8%),2例感染部位为骨骼(18.2%)。大多数培养为多微生物。患者中位年龄为55.5岁(四分位数范围34-63岁),80% (n=8)为男性。沙利拟虫对-内酰胺类、喹诺酮类和万古霉素敏感,对克林霉素、红霉素和甲硝唑耐药。此外,两例糖尿病患者诊断为多微生物糖尿病足骨髓炎从该微生物详细介绍。两例患者均通过靶向抗菌药物治疗和及时手术治疗成功。结论:沙利拟虫是一种新兴病原体,由于分离鉴定困难,可能报道不足。本文还详细介绍了两例糖尿病足骨髓炎,并成功地进行了靶向抗菌治疗和手术清创。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
GERMS
GERMS INFECTIOUS DISEASES-
CiteScore
2.80
自引率
5.00%
发文量
36
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