Impact of inter-observer variability on first axillary level dosimetry in breast cancer radiotherapy: An AIRO multi-institutional study.

IF 2 4区医学 Q3 ONCOLOGY

Tumori Pub Date : 2023-12-01 Epub Date: 2023-09-09 DOI:10.1177/03008916231196801

Maria Cristina Leonardi, Matteo Pepa, Mattia Zaffaroni, Maria Giulia Vincini, Rosa Luraschi, Sabrina Vigorito, Anna Morra, Samantha Dicuonzo, Giovanni Carlo Mazzola, Marianna Alessandra Gerardi, Maria Alessia Zerella, Domenico Cante, Edoardo Petrucci, Giuseppina Borzì, Maristella Marrocco, Matteo Chieregato, Luciano Iadanza, Francesca Lobefalo, Marco Valenti, Anna Cavallo, Serenella Russo, Marika Guernieri, Tiziana Malatesta, Ilaria Meaglia, Marco Liotta, Isabella Palumbo, Marta Marcantonini, Emilio Mezzenga, Sara Falivene, Cecilia Arrichiello, Maria Paola Barbero, Giovanni Battista Ivaldi, Gianpiero Catalano, Cristiana Vidali, Caterina Giannitto, Antonella Ciabattoni, Icro Meattini, Cynthia Aristei, Roberto Orecchia, Federica Cattani, Barbara Alicja Jereczek-Fossa

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引用次数: 0

Abstract

This study quantified the incidental dose to the first axillary level (L1) in locoregional treatment plan for breast cancer. Eighteen radiotherapy centres contoured L1-L4 on three different patients (P1,2,3), created the L2-L4 planning target volume (single centre planning target volume, SC-PTV) and elaborated a locoregional treatment plan. The L2-L4 gold standard clinical target volume (CTV) along with the gold standard L1 contour (GS-L1) were created by an expert consensus. The SC-PTV was then replaced by the GS-PTV and the incidental dose to GS-L1 was measured. Dosimetric data were analysed with Kruskal-Wallis test. Plans were intensity modulated radiotherapy (IMRT)-based. P3 with 90° arm setup had statistically significant higher L1 dose across the board than P1 and P2, with the mean dose (Dmean) reaching clinical significance. Dmean of P1 and P2 was consistent with the literature (77.4% and 74.7%, respectively). The incidental dose depended mostly on L1 proportion included in the breast fields, underlining the importance of the setup, even in case of IMRT.

查看原文本刊更多论文

乳腺癌放疗中第一腋窝水平剂量测定的观察者间变异的影响:一项AIRO多机构研究。

本研究量化了乳腺癌局部局部治疗方案中至腋窝第一水平(L1)的附带剂量。18个放疗中心对3名不同的患者(P1、2、3)绘制L1-L4曲线，创建L2-L4规划靶区(单中心规划靶区，SC-PTV)，并制定局部区域治疗计划。L2-L4金标准临床靶体积(CTV)和金标准L1轮廓(GS-L1)是由专家共识创建的。然后用GS-PTV代替SC-PTV，测量GS-L1的附带剂量。剂量学资料采用Kruskal-Wallis试验进行分析。计划以调强放疗(IMRT)为基础。90°臂位P3组L1剂量全面高于P1和P2组，平均剂量(Dmean)达到临床意义。P1和P2的Dmean与文献一致(分别为77.4%和74.7%)。偶发剂量主要取决于乳腺区域中L1的比例，强调了设置的重要性，即使是在IMRT的情况下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tumori 医学-肿瘤学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Tumori Journal covers all aspects of cancer science and clinical practice with a strong focus on prevention, translational medicine and clinically relevant reports. We invite the publication of randomized trials and reports on large, consecutive patient series that investigate the real impact of new techniques, drugs and devices inday-to-day clinical practice.