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{"title":"Hypoxia in the Pathophysiology of Inflammatory Bowel Disease.","authors":"Michael Morales, Xiang Xue","doi":"10.1002/cphy.c220002","DOIUrl":null,"url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) is an idiopathic disease of disordered chronic inflammation in the intestines that affects many people across the world. While the disease is still being better characterized, greater progress has been made in understanding the many components that intersect in the disease. Among these components are the many pieces that compose the intestinal epithelial barrier, the various cytokines and immune cells, and the population of microbes that reside in the intestinal lumen. Since their discovery, the hypoxia-inducible factors (HIFs) have been found to play an expansive role in physiology as well as diseases such as inflammation due to their role in oxygen sensing-related gene transcription, and metabolic control. Making use of existing and developing paradigms in the immuno-gastroenterology of IBD, we summarized that hypoxic signaling plays as another component in the status and progression of IBD, which may include possible functions at the origins of inflammatory dysregulation. © 2023 American Physiological Society. Compr Physiol 13:4767-4783, 2023.</p>","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10799609/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cphy.c220002","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
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Abstract
Inflammatory bowel disease (IBD) is an idiopathic disease of disordered chronic inflammation in the intestines that affects many people across the world. While the disease is still being better characterized, greater progress has been made in understanding the many components that intersect in the disease. Among these components are the many pieces that compose the intestinal epithelial barrier, the various cytokines and immune cells, and the population of microbes that reside in the intestinal lumen. Since their discovery, the hypoxia-inducible factors (HIFs) have been found to play an expansive role in physiology as well as diseases such as inflammation due to their role in oxygen sensing-related gene transcription, and metabolic control. Making use of existing and developing paradigms in the immuno-gastroenterology of IBD, we summarized that hypoxic signaling plays as another component in the status and progression of IBD, which may include possible functions at the origins of inflammatory dysregulation. © 2023 American Physiological Society. Compr Physiol 13:4767-4783, 2023.
炎症性肠病病理生理学中的缺氧问题。
炎症性肠病(IBD)是一种肠道慢性炎症紊乱的特发性疾病,影响着世界各地的许多人。虽然这种疾病的特征仍在不断完善,但人们在了解这种疾病的许多交叉组成部分方面取得了更大的进展。其中包括构成肠上皮屏障的许多部分、各种细胞因子和免疫细胞,以及居住在肠腔内的微生物群。低氧诱导因子(HIFs)自被发现以来,由于其在氧感应相关基因转录和代谢控制中的作用,在生理和疾病(如炎症)中发挥着广泛的作用。利用现有和正在开发的 IBD 免疫胃肠病学范例,我们总结了缺氧信号在 IBD 的状态和进展中扮演的另一个角色,其中可能包括炎症失调起源的可能功能。© 2023 美国生理学会。Compr Physiol 13:4767-4783, 2023.
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