Increased Dispersion of Ventricular Repolarization as an Arrhythmic Risk Marker in Drug-free Patients With Major Depressive Disorder: A Preliminary Comparative Study.

IF 1.3 4区 医学 Q3 PSYCHIATRY
Yasin H Balcioglu, Hasan Gokcay, Simge S Kirlioglu Balcioglu, Mustafa Solmaz
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引用次数: 0

Abstract

Objective: Drug-free patients with major depressive disorder (MDD) are understudied in terms of increased risk for arrhythmias. In this study, we compared changes in corrected QT interval (QTc), QTc dispersion (QTcd), Tpeak-Tend (Tp-e), Tp-e/QT ratio, corrected JT interval (JTc), and JTc dispersion (JTcd), which are considered to be among the risk factors for the emergence of ventricular arrhythmias in patients with MDD.

Methods: The study involved 50 patients with MDD who had been free of psychotropic medications for at least 1 month and 52 age-matched and sex-matched healthy controls. Illness-related characteristics, including duration of illness and Beck Depression Inventory scores, were recorded. Electrocardiography recordings made under a standardized procedure were performed for all participants, and arrhythmia risk markers were calculated from the electrocardiograms.

Results: The patient group had significantly higher QTcd, JTc, and JTcd values compared with the controls. Among electrocardiogram markers, only Tp-e/QTc was significantly and inversely correlated with the duration of illness, while none of the markers was associated with Beck Depression Inventory scores.

Conclusions: Alterations in electrocardiogram-derived markers of ventricular arrhythmia, which can be obtained easily and inexpensively, can be evaluated for the prediction and prevention of severe cardiac conditions in patients with MDD and considered in selecting the safest antidepressant options available.

作为重度抑郁症无药患者心律失常风险标志物的心室复极化分散性增加:初步比较研究
目的:未服药的重度抑郁症(MDD)患者心律失常风险增加的研究不足。在这项研究中,我们比较了校正 QT 间期 (QTc)、QTc 弥散 (QTcd)、Tpeak-Tend (Tp-e)、Tp-e/QT 比值、校正 JT 间期 (JTc) 和 JTc 弥散 (JTcd) 的变化,这些变化被认为是 MDD 患者出现室性心律失常的风险因素之一:这项研究涉及 50 名已停用精神药物至少 1 个月的 MDD 患者和 52 名年龄和性别匹配的健康对照者。研究人员记录了与疾病相关的特征,包括病程和贝克抑郁量表评分。按照标准化程序对所有参与者进行心电图记录,并根据心电图计算心律失常风险指标:结果:与对照组相比,患者组的 QTcd、JTc 和 JTcd 值明显较高。在心电图指标中,只有Tp-e/QTc与病程显著成反比,而没有一个指标与贝克抑郁量表评分相关:心电图衍生的室性心律失常标记物的变化可以通过评估来预测和预防 MDD 患者的严重心脏疾病,并在选择最安全的抗抑郁药物时加以考虑。
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来源期刊
CiteScore
2.30
自引率
10.50%
发文量
159
审稿时长
>12 weeks
期刊介绍: Journal of Psychiatric Practice® seizes the day with its emphasis on the three Rs — readability, reliability, and relevance. Featuring an eye-catching style, the journal combines clinically applicable reviews, case studies, and articles on treatment advances with practical and informative tips for treating patients. Mental health professionals will want access to this review journal — for sharpening their clinical skills, discovering the best in treatment, and navigating this rapidly changing field. Journal of Psychiatric Practice combines clinically applicable reviews, case studies, and articles on treatment advances with informative "how to" tips for surviving in a managed care environment.
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