Chlamydia trachomatis Serovar Distribution in Patients with Follicular Conjunctivitis in Iran.

Q3 Medicine

Turkish Journal of Ophthalmology Pub Date : 2023-08-19 DOI:10.4274/tjo.galenos.2022.12080

Zohreh Abedifar, Fatemeh Fallah, Fahimeh Asadiamoli, Ben Bourrie, Farahnoosh Doustdar

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引用次数: 0

Abstract

Objectives: Chlamydia trachomatis infects the urogenital tract and eyes. Anatomical tropism is correlated with serovars which are characterized according to the variation in the major outer membrane proteins encoded by the ompA gene. The aim of the present study was to determine the distribution of C. trachomatis serovars among patients with follicular conjunctivitis in Iran.

Materials and methods: A total of 68 conjunctival specimens from symptomatic adults were studied for the presence of C. trachomatis using polymerase chain reaction (PCR) analysis. Serovars were determined by Omp1 PCR-RFLP analysis.

Results: C. trachomatis was detected in 38 (55.9%) of patients with follicular conjunctivitis, with higher C. trachomatis prevalence in the younger age groups. Twenty-six (38.2%) of these patients had a history of urinary tract infection. Four distinct serovars were identified in the conjunctiva samples using molecular genotyping. The most prevalent was serovar E, followed by G, I, and F.

Conclusion: Our serovar distribution indicated that chlamydial follicular conjunctivitis usually has a genital source. Genital serovars may cause eye diseases, especially in sexually active adults. On the other hand, conjunctivitis might be the only sign of sexually transmitted infection. Therefore, genotyping C. trachomatis in ocular and genital specimens could be beneficial for acquiring more detailed epidemiological information about the etiology of the disease and monitoring treatment success.

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伊朗滤泡性结膜炎患者沙眼衣原体血清分布。

目的:沙眼衣原体感染泌尿生殖道和眼睛。解剖向性与血清型相关，血清型的特征是由ompA基因编码的主要外膜蛋白的变化。本研究的目的是确定伊朗滤泡性结膜炎患者中沙眼原体血清型的分布。材料与方法:采用聚合酶链反应(PCR)方法对68份有症状成人结膜标本进行沙眼原体检测。采用Omp1 PCR-RFLP分析血清型。结果:滤泡性结膜炎检出沙眼衣原体38例(55.9%)，年龄越小沙眼衣原体患病率越高。26例(38.2%)患者有尿路感染史。使用分子基因分型在结膜样本中鉴定出四种不同的血清型。结论:我们的血清分布表明衣原体滤泡性结膜炎通常有生殖器来源。生殖器血清型可引起眼部疾病，特别是在性活跃的成年人中。另一方面，结膜炎可能是性传播感染的唯一迹象。因此，对眼部和生殖器标本中的沙眼衣原体进行基因分型，可能有助于获得有关该病病因的更详细的流行病学信息和监测治疗成功情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish Journal of Ophthalmology Medicine-Ophthalmology

CiteScore

2.20

自引率

0.00%

发文量

期刊介绍： The Turkish Journal of Ophthalmology (TJO) is the only scientific periodical publication of the Turkish Ophthalmological Association and has been published since January 1929. In its early years, the journal was published in Turkish and French. Although there were temporary interruptions in the publication of the journal due to various challenges, the Turkish Journal of Ophthalmology has been published continually from 1971 to the present. The target audience includes specialists and physicians in training in ophthalmology in all relevant disciplines.