A healthy mind in a healthy body: Effects of arteriosclerosis and other risk factors on cognitive aging and dementia.

4区 心理学 Q2 Psychology
Psychology of Learning and Motivation Pub Date : 2022-01-01 Epub Date: 2022-09-07 DOI:10.1016/bs.plm.2022.08.001
Monica Fabiani, Bethlehem A Asnakew, Daniel C Bowie, Sydney M Chism, Grace M Clements, Jennie C Gardner, Samia S Islam, Samantha L Rubenstein, Gabriele Gratton
{"title":"A healthy mind in a healthy body: Effects of arteriosclerosis and other risk factors on cognitive aging and dementia.","authors":"Monica Fabiani,&nbsp;Bethlehem A Asnakew,&nbsp;Daniel C Bowie,&nbsp;Sydney M Chism,&nbsp;Grace M Clements,&nbsp;Jennie C Gardner,&nbsp;Samia S Islam,&nbsp;Samantha L Rubenstein,&nbsp;Gabriele Gratton","doi":"10.1016/bs.plm.2022.08.001","DOIUrl":null,"url":null,"abstract":"<p><p>In this review we start from the assumption that, to fully understand cognitive aging, it is important to embrace a holistic view, integrating changes in bodily, brain, and cognitive functions. This broad view can help explain individual differences in aging trajectories and could ultimately enable prevention and remediation strategies. As the title of this review suggests, we claim that there are not only indirect but also direct effects of various organ systems on the brain, creating cascades of phenomena that strongly contribute to age-related cognitive decline. Here we focus primarily on the cerebrovascular system, because of its direct effects on brain health and close connections with the development and progression of Alzheimer's Disease and other types of dementia. We start by reviewing the main cognitive changes that are often observed in normally aging older adults, as well as the brain systems that support them. Second, we provide a brief overview of the cerebrovascular system and its known effects on brain anatomy and function, with a focus on aging. Third, we review genetic and lifestyle risk factors that may affect the cerebrovascular system and ultimately contribute to cognitive decline. Lastly, we discuss this evidence, review limitations, and point out avenues for additional research and clinical intervention.</p>","PeriodicalId":47830,"journal":{"name":"Psychology of Learning and Motivation","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153623/pdf/nihms-1845356.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychology of Learning and Motivation","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1016/bs.plm.2022.08.001","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/9/7 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Psychology","Score":null,"Total":0}
引用次数: 1

Abstract

In this review we start from the assumption that, to fully understand cognitive aging, it is important to embrace a holistic view, integrating changes in bodily, brain, and cognitive functions. This broad view can help explain individual differences in aging trajectories and could ultimately enable prevention and remediation strategies. As the title of this review suggests, we claim that there are not only indirect but also direct effects of various organ systems on the brain, creating cascades of phenomena that strongly contribute to age-related cognitive decline. Here we focus primarily on the cerebrovascular system, because of its direct effects on brain health and close connections with the development and progression of Alzheimer's Disease and other types of dementia. We start by reviewing the main cognitive changes that are often observed in normally aging older adults, as well as the brain systems that support them. Second, we provide a brief overview of the cerebrovascular system and its known effects on brain anatomy and function, with a focus on aging. Third, we review genetic and lifestyle risk factors that may affect the cerebrovascular system and ultimately contribute to cognitive decline. Lastly, we discuss this evidence, review limitations, and point out avenues for additional research and clinical intervention.

Abstract Image

Abstract Image

健康的身心:动脉硬化和其他危险因素对认知衰老和痴呆的影响。
在这篇综述中,我们从这样一个假设开始,即要充分理解认知衰老,重要的是要接受一个整体的观点,综合身体、大脑和认知功能的变化。这种广泛的观点可以帮助解释衰老轨迹中的个体差异,并最终实现预防和补救策略。正如这篇综述的标题所表明的那样,我们声称各种器官系统对大脑的影响不仅是间接的,而且是直接的,产生了一系列现象,这些现象强烈导致了与年龄相关的认知能力下降。在这里,我们主要关注脑血管系统,因为它对大脑健康有直接影响,并且与阿尔茨海默病和其他类型痴呆的发展和进展密切相关。我们首先回顾了在正常衰老的老年人中经常观察到的主要认知变化,以及支持这些变化的大脑系统。其次,我们简要概述了脑血管系统及其对大脑解剖和功能的已知影响,重点是衰老。第三,我们回顾了可能影响脑血管系统并最终导致认知能力下降的遗传和生活方式风险因素。最后,我们讨论了这一证据,回顾了其局限性,并指出了进一步研究和临床干预的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Psychology of Learning and Motivation
Psychology of Learning and Motivation PSYCHOLOGY, EXPERIMENTAL-
CiteScore
3.30
自引率
0.00%
发文量
14
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信