Fang Fang, Linran Zhou, Wei Perng, Carmen J Marsit, Anna K Knight, Andres Cardenas, Max T Aung, Marie-France Hivert, Izzuddin M Aris, Jaclyn M Goodrich, Alicia K Smith, Abigail Gaylord, Rebecca C Fry, Emily Oken, George O'Connor, Douglas M Ruden, Leonardo Trasande, Julie B Herbstman, Carlos A Camargo, Nicole R Bush, Anne L Dunlop, Dana M Dabelea, Margaret R Karagas, Carrie V Breton, Carole Ober, Todd M Everson, Grier P Page, Christine Ladd-Acosta
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引用次数: 0
Abstract
Background: Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.
Results: Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples.
Conclusions: Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.
Clinical EpigeneticsBiochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
8.90
自引率
5.30%
发文量
150
审稿时长
12 weeks
期刊介绍:
Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.