Themes and variations on piRNA-guided transposon control.

IF 4.7 2区 生物学 Q1 GENETICS & HEREDITY
Zuzana Loubalova, Parthena Konstantinidou, Astrid D Haase
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引用次数: 0

Abstract

PIWI-interacting RNAs (piRNAs) are responsible for preventing the movement of transposable elements in germ cells and protect the integrity of germline genomes. In this review, we examine the common elements of piRNA-guided silencing as well as the differences observed between species. We have categorized the mechanisms of piRNA biogenesis and function into modules. Individual PIWI proteins combine these modules in various ways to produce unique PIWI-piRNA pathways, which nevertheless possess the ability to perform conserved functions. This modular model incorporates conserved core mechanisms and accommodates variable co-factors. Adaptability is a hallmark of this RNA-based immune system. We believe that considering the differences in germ cell biology and resident transposons in different organisms is essential for placing the variations observed in piRNA biology into context, while still highlighting the conserved themes that underpin this process.

Abstract Image

Abstract Image

Abstract Image

pirna引导转座子控制的主题和变化。
piwi相互作用rna (pirna)负责阻止生殖细胞中转座因子的移动并保护种系基因组的完整性。在这篇综述中,我们研究了pirna引导的沉默的共同因素以及在物种之间观察到的差异。我们将piRNA的生物发生机制和功能分为几个模块。单个PIWI蛋白以不同的方式结合这些模块来产生独特的PIWI- pirna通路,然而这些通路具有执行保守功能的能力。这种模块化模型结合了保守的核心机制,并适应了可变的辅助因素。适应性是这种基于rna的免疫系统的标志。我们认为,考虑生殖细胞生物学和常驻转座子在不同生物体中的差异,对于将在piRNA生物学中观察到的变化置于背景中是必不可少的,同时仍然强调支撑这一过程的保守主题。
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来源期刊
Mobile DNA
Mobile DNA GENETICS & HEREDITY-
CiteScore
8.20
自引率
6.10%
发文量
26
审稿时长
11 weeks
期刊介绍: Mobile DNA is an online, peer-reviewed, open access journal that publishes articles providing novel insights into DNA rearrangements in all organisms, ranging from transposition and other types of recombination mechanisms to patterns and processes of mobile element and host genome evolution. In addition, the journal will consider articles on the utility of mobile genetic elements in biotechnological methods and protocols.
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