Lung cancer: Premalignant biology and medical prevention

IF 3 3区医学 Q2 ONCOLOGY

Seminars in oncology Pub Date : 2022-06-01 DOI:10.1053/j.seminoncol.2022.02.001

R.L. Keith , Y.E. Miller , M. Ghosh , Wilbur A. Franklin , I. Nakachi , D.T. Merrick

引用次数: 1

Abstract

Lung cancer (both adenocarcinoma and squamous cell) progress through a series of pre-malignant histologic changes before the development of invasive disease. Each of these carcinogenic cascades is defined by genetic and epigenetic alterations in pulmonary epithelial cells. Additionally, alterations in the immune response, progenitor cell function, mutational burden, and microenvironmental mediated survival of mutated clones contribute to the risk of pre-malignant lesions progressing to cancer. Medical preventions studies have been completed and current and future trials are informed by the improved understanding of pre-malignancy. This will lead to precision chemoprevention trials based on lesional biology and histologic characteristics.

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肺癌:癌前生物学和医学预防

肺癌(包括腺癌和鳞状细胞癌)在发展为侵袭性疾病之前通过一系列癌前组织学变化进展。每一种致癌级联反应都是由肺上皮细胞的遗传和表观遗传改变来定义的。此外，免疫反应、祖细胞功能、突变负担和突变克隆的微环境介导存活的改变有助于恶性病变进展为癌症的风险。医学预防研究已经完成，目前和未来的试验都是基于对恶性肿瘤前期的进一步了解。这将导致基于病变生物学和组织学特征的精确化学预防试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in oncology 医学-肿瘤学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

104 days

期刊介绍： Seminars in Oncology brings you current, authoritative, and practical reviews of developments in the etiology, diagnosis and management of cancer. Each issue examines topics of clinical importance, with an emphasis on providing both the basic knowledge needed to better understand a topic as well as evidence-based opinions from leaders in the field. Seminars in Oncology also seeks to be a venue for sharing a diversity of opinions including those that might be considered "outside the box". We welcome a healthy and respectful exchange of opinions and urge you to approach us with your insights as well as suggestions of topics that you deem worthy of coverage. By helping the reader understand the basic biology and the therapy of cancer as they learn the nuances from experts, all in a journal that encourages the exchange of ideas we aim to help move the treatment of cancer forward.