The impact of serum estradiol and progesterone levels during implantation on obstetrical complications and perinatal outcomes in frozen embryo transfer.

IF 1.9 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of the Chinese Medical Association Pub Date : 2024-03-01 Epub Date: 2023-09-11 DOI:10.1097/JCMA.0000000000000988

Yi-Lun Lin, Chung-Han Ho, Ming-Ting Chung, Liang-Yin Lin, Tsun-Wen Hsiao, Yi-Ting Chen, Jen-Yu Wen, Yung-Chieh Tsai

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引用次数: 0

Abstract

Background: This study sought to evaluate obstetric complications and perinatal outcomes in frozen embryo transfer (FET) using either a natural cycle (NC-FET) or a hormone therapy cycle (HT-FET). Furthermore, we investigated how serum levels of estradiol (E2) and progesterone (P4) on the day of and 3 days after embryo transfer (ET) correlated with clinical outcomes in the two groups.

Methods: We conducted a retrospective, single-center study from January 1, 2015, to December 31, 2019. The study included couples who underwent NC-FET or HT-FET resulting in a singleton live birth. Serum levels of E2 and P4 were measured on the day of and 3 days after ET. The primary outcomes assessed were preterm birth rate, low birth weight, macrosomia, hypertensive disorders in pregnancy, gestational diabetes mellitus, postpartum hemorrhage, and placenta-related complications.

Results: A total of 229 singletons were included, with 49 in the NC-FET group and 180 in the HT-FET group. There were no significant differences in obstetric complications and perinatal outcomes between the two groups. The NC-FET group had significantly higher serum levels of P4 (17.2 ng/mL vs 8.85 ng/mL; p < 0.0001) but not E2 (144 pg/mL vs 147 pg/mL; p = 0.69) on the day of ET. Additionally, 3 days after ET, the NC-FET group had significantly higher levels of both E2 (171 pg/mL vs 140.5 pg/mL; p = 0.0037) and P4 (27.3 ng/mL vs 11.7 ng/mL; p < 0.0001) compared with the HT-FET group.

Conclusion: Our study revealed that although there were significant differences in E2 and P4 levels around implantation between the two groups, there were no significant differences in obstetric complications and perinatal outcomes. Therefore, the hormonal environment around implantation did not appear to be the primary cause of differences in obstetric and perinatal outcomes between the two EM preparation methods used in FET.

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植入过程中血清雌二醇和孕酮水平对冷冻胚胎移植的产科并发症和围产期结果的影响。

背景：本研究旨在评估采用自然周期（NC-FET）或激素治疗周期（HT-FET）进行冷冻胚胎移植（FET）的产科并发症和围产期结局。此外，我们还研究了胚胎移植（ET）当天和三天后血清中雌二醇（E2）和孕酮（P4）水平与两组临床结果的相关性：我们从 2015 年 1 月 1 日至 2019 年 12 月 31 日进行了一项回顾性单中心研究。研究对象包括接受NC-FET或HT-FET并最终获得单胎活产的夫妇。在ET当天和3天后测量血清中的E2和P4水平。评估的主要结果包括早产率、低出生体重、巨大儿、妊娠期高血压疾病、妊娠期糖尿病、产后出血和胎盘相关并发症：共纳入 229 例单胎，其中 NC-FET 组 49 例，HT-FET 组 180 例。两组在产科并发症和围产期结果方面无明显差异。NC-FET组在ET当天的血清P4水平（17.2纳克/毫升 vs 8.85纳克/毫升；p < 0.0001）明显高于HT-FET组，但E2水平（144皮克/毫升 vs 147皮克/毫升；p = 0.69）不明显高于NC-FET组。此外，ET 3 天后，NC-FET 组的 E2 水平（171 pg/mL vs 140.5 pg/mL；p = 0.0037）和 P4 水平（27.3 ng/mL vs 11.7 ng/mL；p < 0.0001）均显著高于 HT-FET 组：我们的研究表明，虽然两组患者在植入前后的E2和P4水平存在显著差异，但在产科并发症和围产期结局方面没有显著差异。因此，植入前后的荷尔蒙环境似乎并不是FET中使用的两种EM准备方法之间产科和围产期结果差异的主要原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Chinese Medical Association MEDICINE, GENERAL & INTERNAL-

CiteScore

6.20

自引率

13.30%

发文量

320

审稿时长

15.5 weeks

期刊介绍： Journal of the Chinese Medical Association, previously known as the Chinese Medical Journal (Taipei), has a long history of publishing scientific papers and has continuously made substantial contribution in the understanding and progress of a broad range of biomedical sciences. It is published monthly by Wolters Kluwer Health and indexed in Science Citation Index Expanded (SCIE), MEDLINE®, Index Medicus, EMBASE, CAB Abstracts, Sociedad Iberoamericana de Informacion Cientifica (SIIC) Data Bases, ScienceDirect, Scopus and Global Health. JCMA is the official and open access journal of the Chinese Medical Association, Taipei, Taiwan, Republic of China and is an international forum for scholarly reports in medicine, surgery, dentistry and basic research in biomedical science. As a vehicle of communication and education among physicians and scientists, the journal is open to the use of diverse methodological approaches. Reports of professional practice will need to demonstrate academic robustness and scientific rigor. Outstanding scholars are invited to give their update reviews on the perspectives of the evidence-based science in the related research field. Article types accepted include review articles, original articles, case reports, brief communications and letters to the editor

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