Fructose Consumption Alters Biogenic Amines Associated with Cardiovascular Disease Risk Factors.

IF 2 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Arquivos Brasileiros de Cardiologia Pub Date : 2023-05-01 DOI:10.36660/abc.20220770

Fabiane Valentini Francisqueti-Ferron, Matheus Antônio Filiol Belin, Thiago Luiz Novaga Palacio, Artur Junio Togneri Ferron, Jéssica Leite Garcia, Juliana Silva Siqueira, Erika Tiemi Nakandakare-Maia, Taynara Aparecida Vieira, Hugo Tadashi Kano, Fernando Moreto, Giuseppina Pace Pereira Lima, Camila Renata Corrêa, Igor Otavio Minatel

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引用次数: 0

Abstract

Background: Cardiovascular diseases (CVD) are the major cause of mortality worldwide, whose most prominent risk factor is unhealthy eating habits, such as high fructose intake. Biogenic amines (BAs) perform important functions in the human body. However, the effect of fructose consumption on BA levels is still unclear, as is the association between these and CVD risk factors.

Objective: This study aimed to establish the association between BA levels and CVD risk factors in animals that consumed fructose.

Methods: Male Wistar rats received standard chow (n=8) or standard chow + fructose in drinking water (30%) (n=8) over a 24-week period. At the end of this period, the nutritional and metabolic syndrome (MS) parameters and plasmatic BA levels were analyzed. A 5% level of significance was adopted.

Results: Fructose consumption led to MS, reduced the levels of tryptophan and 5-hydroxitryptophan, and increased histamine. Tryptophan, histamine, and dopamine showed a correlation with metabolic syndrome parameters.

Conclusion: Fructose consumption alters BAs associated with CVD risk factors.

Abstract Image

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果糖摄入改变与心血管疾病危险因素相关的生物胺

背景:心血管疾病(CVD)是世界范围内死亡的主要原因，其最突出的危险因素是不健康的饮食习惯，如高果糖摄入。生物胺(BAs)在人体中发挥着重要的作用。然而，果糖摄入对BA水平的影响仍不清楚，BA水平与心血管疾病风险因素之间的关系也不清楚。目的:本研究旨在确定摄入果糖的动物体内BA水平与CVD危险因素之间的关系。方法:雄性Wistar大鼠给予标准饲料(n=8)或标准饲料+饮用水中果糖(30%)(n=8)，为期24周。在这段时间结束时，分析营养和代谢综合征(MS)参数和血浆BA水平。采用5%显著性水平。结果:果糖摄入导致多发性硬化症，降低色氨酸和5-羟色氨酸水平，增加组胺。色氨酸、组胺和多巴胺与代谢综合征参数相关。结论:果糖摄入改变了与CVD危险因素相关的BAs。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos Brasileiros de Cardiologia 医学-心血管系统

CiteScore

3.70

自引率

30.80%

发文量

234

审稿时长

3-8 weeks

期刊介绍： With more than 70 years of existence, Arquivos Brasileiros de Cardiologia is the main channel for the dissemination of Brazilian scientific research on cardiovascular sciences. Published in two languages and indexed in major international databases, all scientific contributions are peer-reviewed and reviewed by editorial board members selected among the most reputable researchers in Brazil and abroad. The manuscripts are reviewed according to their relevance and originality, scientific accuracy and level of importance for the advancement of science. With an average time of nine months between the initial submission and the effective publication of the manuscripts, and less than seven months until they are published on PubMed, Arquivos Brasileiros de Cardiologia can ensure the quick inclusion of the researchers’ papers in the international literature.