WITHDRAWN: Cell based dATP delivery as a therapy for chronic heart failure.

Ketaki N Mhatre, Julie Mathieu, Amy Martinson, Galina Flint, Leslie P Blakley, Arash Tabesh, Hans Reinecke, Xiulan Yang, Xuan Guan, Eesha Murali, Jordan M Klaiman, Guy L Odom, Mary Beth Brown, Rong Tian, Stephen D Hauschka, Daniel Raftery, Farid Moussavi-Harami, Michael Regnier, Charles E Murry
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Abstract

The authors have withdrawn this manuscript because the senior authors have identified inconsistencies in the data presented in this manuscript, which affect the reliability of the main conclusions. In keeping with our commitment to scientific rigor and transparency, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding authors.

Abstract Image

Abstract Image

Abstract Image

基于细胞的dATP递送作为慢性心力衰竭的治疗方法。
移植的人多能干细胞来源的心肌细胞(hPSC CMs)在心肌梗死后急性输送时可改善心室性能,但在慢性心肌梗死/心力衰竭中无效。2'-脱氧ATP(dATP)激活心肌肌球蛋白并有效地增加收缩性。在这里,我们设计了hPSC CMs来过表达核糖核苷酸还原酶,这种酶控制dATP的产生。在体内,产生dATP的CM形成了新的心肌,通过间隙连接将dATP转移到宿主心肌细胞,增加了它们的dATP水平。引人注目的是,当移植到慢性梗死的心脏中时,产生dATP的移植物会增加左心室功能,而野生型移植物或载体注射会使心力衰竭恶化。dATP供体细胞受体有更多的自主运动,改善心脏代谢,减少肺充血和病理性心脏肥大,并提高生存率。这种再肌肉化加上增强宿主收缩力的组合为治疗慢性衰竭的心脏提供了一种新的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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