Resonance Raman Spectroscopy Tissue Oxygenation Measurements in Neonates.

IF 2.6 3区医学 Q1 PEDIATRICS

Neonatology Pub Date : 2023-01-01 DOI:10.1159/000529624

Tazuddin Azmi Mohammed, Russell Ray Moores, Karen D Hendricks-Muñoz, Padraic Romfh, Henry J Rozycki

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Abstract

Introduction: Current oxygen monitoring by pulse oximetry has limitations and cannot provide estimates of the oxygen content in the microvasculature, where oxygen is used. Resonance Raman spectroscopy (RRS) provides noninvasive microvascular oxygen measurement. The objectives of this study were to (i) measure the correlation between preductal RRS microvascular oxygen saturations (RRS-StO2) and central venous oxygen saturation (SCVO2), (ii) develop normative data for RRS-StO2 measurements in healthy preterm infants, and (iii) determine the effect of blood transfusion on RRS-StO2.

Methods: Thirty-three buccal and thenar RRS-StO2 measurements were performed in 26 subjects to correlate RRS-StO2 with SCVO2. Thirty-one measurements were performed in 28 subjects to develop normative RRS-StO2 values, and eight subjects were enrolled in the transfusion group to assess changes in RRS-StO2 with blood transfusion.

Results: There were good correlations for buccal (r = 0.692) and thenar (r = 0.768) RRS-StO2 versus SCVO2. The median RRS-StO2 in healthy subjects was 76% (IQR 68.7-80.8). There was a significant increase of 7.8 ± 4.6% in the thenar RRS-StO2 after blood transfusion.

Conclusions: RRS appears to be a safe and noninvasive means of monitoring microvascular oxygenation. Thenar RRS-StO2 measurements are more feasible and practical to use than buccal. In healthy preterm infants, the median RRS-StO2 was calculated based on measurements across various gestational age and gender. More studies evaluating the effects of gestational age of RRS-StO2 in various critical clinical settings are needed to confirm the findings.

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新生儿的共振拉曼光谱组织氧合测量。

目前脉搏血氧仪的氧气监测有局限性，不能提供使用氧气的微血管中氧含量的估计。共振拉曼光谱(RRS)提供无创微血管氧测量。本研究的目的是(i)测量产前RRS微血管氧饱和度(RRS- sto2)和中心静脉氧饱和度(SCVO2)之间的相关性，(ii)制定健康早产儿RRS- sto2测量的规范数据，以及(iii)确定输血对RRS- sto2的影响。方法:对26名受试者进行33次口腔和鱼际RRS-StO2测量，以确定RRS-StO2与SCVO2的相关性。在28名受试者中进行31项测量以获得规范的RRS-StO2值，并将8名受试者纳入输血组以评估输血后RRS-StO2的变化。结果:颊部(r = 0.692)和鱼际(r = 0.768) RRS-StO2与SCVO2有良好的相关性。健康受试者RRS-StO2中位数为76% (IQR 68.7-80.8)。输血后大鱼际RRS-StO2显著升高7.8±4.6%。结论:RRS是一种安全、无创的微血管氧合监测手段。大鱼际RRS-StO2测量比颊部更可行和实用。在健康早产儿中，RRS-StO2的中位数是根据不同胎龄和性别的测量结果计算的。需要更多的研究来评估胎龄对RRS-StO2在各种关键临床环境中的影响，以证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neonatology 医学-小儿科

CiteScore

0.60

自引率

4.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomized trials, observational studies and epidemiology. Basic science research covers molecular biology, molecular genetics, physiology, biochemistry and pharmacology in fetal and neonatal life. In addition to the classic features the journal accepts papers for the sections Research Briefings and Sources of Neonatal Medicine (historical pieces). Papers reporting results of animal studies should be based upon hypotheses that relate to developmental processes or disorders in the human fetus or neonate.