Interleukin-33 and Soluble ST2 Levels in Infants with Hypoxic-Ischemic Encephalopathy.

IF 2.6 3区医学 Q1 PEDIATRICS

Neonatology Pub Date : 2023-01-01 DOI:10.1159/000529679

Hiroki Hamano, Kazumasa Takahashi, Sasagu Kimura, Chie Matsuguma, Hidenobu Kaneyasu, Yosuke Fujimoto, Naoki Ohta, Seigo Okada, Shunji Hasegawa

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引用次数: 0

Abstract

Introduction: Interleukin (IL)-33 and its receptor ST2L play key roles in the IL-33/ST2 signaling pathway. Soluble ST2 (sST2) inhibits the proper function of IL-33. sST2 levels are increased in patients with several neurological diseases, but in infants with hypoxic-ischemic encephalopathy (HIE), IL-33 and sST2 levels have not been studied. This study aimed to investigate whether serum levels of IL-33 and sST2 are useful as biomarkers of HIE severity and prognostic factors for infants with HIE.

Methods: Twenty-three infants with HIE and 16 controls (gestational age ≥36 weeks and ≥1,800 g birth weight) were enrolled in this study. Serum levels of IL-33 and sST2 were measured at <6 h, 1-2, 3, and 7 days of age. Hydrogen-1 magnetic resonance spectroscopy was performed, and ratios of peak integrals of lactate/N-acetylaspartate (Lac/NAA) were calculated as objective indicators of brain damage.

Results: In the moderate and severe HIE, serum sST2 concentrations were increased and there was a good correlation between serum sST2 and HIE severity on days 1-2, whereas no variation was observed in serum IL-33. Serum sST2 levels were positively correlated with Lac/NAA ratios (Kendall's rank correlation coefficient = 0.527, p = 0.024), and both sST2 and Lac/NAA ratios were significantly higher in HIE infants with neurological impairment (p = 0.020 and <0.001, respectively).

Conclusions: sST2 may be a useful predictor of severity and later neurological outcomes in infants with HIE. Further investigation is required to elucidate the relationship between the IL-33/ST2 axis and HIE.

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缺氧缺血性脑病患儿白细胞介素-33和可溶性ST2水平

白细胞介素(Interleukin, IL)-33及其受体ST2L在IL-33/ST2信号通路中起关键作用。可溶性ST2 (sST2)抑制IL-33的正常功能。sST2水平在几种神经系统疾病患者中升高，但在缺氧缺血性脑病(HIE)婴儿中，IL-33和sST2水平尚未研究。本研究旨在探讨血清IL-33和sST2水平是否可作为HIE患儿严重程度的生物标志物和预后因素。方法:23例HIE患儿和16例对照组(胎龄≥36周，出生体重≥1800 g)。结果:中重度HIE患者血清中IL-33和sST2浓度升高，1-2天血清中sST2浓度与HIE严重程度有良好的相关性，而血清中IL-33水平无变化。血清sST2水平与Lac/NAA比值呈正相关(肯达尔秩相关系数= 0.527,p = 0.024)，伴有神经功能损害的HIE婴儿血清sST2和Lac/NAA比值均显著较高(p = 0.020)。结论:sST2可能是HIE婴儿严重程度和后期神经预后的有用预测因子。IL-33/ST2轴与HIE之间的关系有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neonatology 医学-小儿科

CiteScore

0.60

自引率

4.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomized trials, observational studies and epidemiology. Basic science research covers molecular biology, molecular genetics, physiology, biochemistry and pharmacology in fetal and neonatal life. In addition to the classic features the journal accepts papers for the sections Research Briefings and Sources of Neonatal Medicine (historical pieces). Papers reporting results of animal studies should be based upon hypotheses that relate to developmental processes or disorders in the human fetus or neonate.