Overnight Heart Rate Variability During Sleep Disturbance In Peri- And Postmenopausal Women.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

Behavioral Sleep Medicine Pub Date : 2024-05-01 Epub Date: 2023-09-06 DOI:10.1080/15402002.2023.2255329

Irina Virtanen, Päivi Polo-Kantola, Nea Kalleinen

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引用次数: 0

Abstract

Objectives: Disturbed sleep, common during the climacteric, is associated with increased sympathetic activity, a cardiovascular risk factor. We evaluated sleep disturbance effect on autonomic nervous function in climacteric women.

Methods: Seventeen perimenopausal and 18 postmenopausal women underwent a sleep study protocol: an adaptation night, a reference night, and a sleep disturbance night, with a hand loosely tied to the bed to allow blood sampling. This procedure was repeated after six months of menopausal hormone therapy (MHT) or placebo. Sleep disturbance and MHT effects on overnight heart rate variability (HRV) were analyzed.

Results: At baseline, sleep disturbance increased vagal HRV in postmenopausal women, but no changes were seen in perimenopausal women. At six months, sleep disturbance increased total HRV power in the perimenopausal placebo group, and increased nonlinear vagal HRV in the postmenopausal placebo group, but no other changes were seen. MHT did not have any effects on HRV, neither at perimenopause nor at postmenopause.

Conclusions: External sleep disturbance had only minor effects on HRV across menopause. MHT had no detectable HRV effects.

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围绝经期和绝经后妇女睡眠紊乱期间的隔夜心率变异性

目的：睡眠紊乱在女性更年期很常见，与交感神经活动增加有关，而交感神经活动增加是心血管风险因素之一。我们评估了睡眠障碍对高潮期女性自律神经功能的影响：17名围绝经期妇女和18名绝经后妇女接受了睡眠研究方案：一个适应之夜、一个参照之夜和一个睡眠障碍之夜。在接受更年期荷尔蒙疗法（MHT）或安慰剂治疗六个月后，重复这一过程。分析了睡眠障碍和 MHT 对夜间心率变异性（HRV）的影响：结果：基线时，睡眠障碍会增加绝经后妇女迷走神经的心率变异性，但围绝经期妇女的心率变异性没有变化。六个月后，睡眠障碍增加了围绝经期安慰剂组的总心率变异功率，增加了绝经后安慰剂组的非线性迷走心率变异，但未发现其他变化。无论是在围绝经期还是绝经后，MHT对心率变异都没有任何影响：结论：外部睡眠障碍对整个绝经期的心率变异只有轻微影响。MHT对心率变异没有可检测到的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioral Sleep Medicine CLINICAL NEUROLOGY-PSYCHIATRY

CiteScore

7.20

自引率

3.20%

发文量

审稿时长

>12 weeks

期刊介绍： Behavioral Sleep Medicine addresses behavioral dimensions of normal and abnormal sleep mechanisms and the prevention, assessment, and treatment of sleep disorders and associated behavioral and emotional problems. Standards for interventions acceptable to this journal are guided by established principles of behavior change. Intending to serve as the intellectual home for the application of behavioral/cognitive science to the study of normal and disordered sleep, the journal paints a broad stroke across the behavioral sleep medicine landscape. Its content includes scholarly investigation of such areas as normal sleep experience, insomnia, the relation of daytime functioning to sleep, parasomnias, circadian rhythm disorders, treatment adherence, pediatrics, and geriatrics. Multidisciplinary approaches are particularly welcome. The journal’ domain encompasses human basic, applied, and clinical outcome research. Behavioral Sleep Medicine also embraces methodological diversity, spanning innovative case studies, quasi-experimentation, randomized trials, epidemiology, and critical reviews.