mRNA-Based Nanomedicine: A New Strategy for Treating Infectious Diseases and Beyond.

IF 1.9 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Satyendra Prakash
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引用次数: 0

Abstract

Messenger RNA (mRNA) has emerged as a new therapeutic agent for the prevention and treatment of a wide range of diseases. The recent achievement of the two lipid nanoparticle-mRNA vaccines developed by Moderna and Pfizer-BioNTech against coronavirus 2019 (COVID-19) disease in record time highlights the huge potential of mRNA technology and reshaping the landscape of vaccine development and the future of gene therapies. Challenges related to translational efficacy, mRNA stability, immunogenicity, and ensuring the quality of final products have been significantly improved by recent advancements in mRNA engineering and delivery. Thus, the present review aims to provide the latest innovations that incrementally overcome these issues and future directions in the context of ongoing clinical trials against infectious diseases and beyond.

Abstract Image

基于mrna的纳米医学:治疗传染病及其他疾病的新策略。
信使RNA (mRNA)已成为预防和治疗多种疾病的一种新的治疗剂。Moderna和Pfizer-BioNTech最近在创纪录的时间内开发了两种针对2019冠状病毒(COVID-19)疾病的脂质纳米颗粒-mRNA疫苗,这突显了mRNA技术的巨大潜力,并重塑了疫苗开发和基因治疗的未来。随着mRNA工程和传递的最新进展,与翻译效率、mRNA稳定性、免疫原性和确保最终产物质量相关的挑战已经得到了显著改善。因此,本综述旨在提供最新的创新,以逐步克服这些问题,并在正在进行的针对传染病和其他疾病的临床试验的背景下确定未来的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
64
审稿时长
>12 weeks
期刊介绍: Hepatology International is a peer-reviewed journal featuring articles written by clinicians, clinical researchers and basic scientists is dedicated to research and patient care issues in hepatology. This journal focuses mainly on new and emerging diagnostic and treatment options, protocols and molecular and cellular basis of disease pathogenesis, new technologies, in liver and biliary sciences. Hepatology International publishes original research articles related to clinical care and basic research; review articles; consensus guidelines for diagnosis and treatment; invited editorials, and controversies in contemporary issues. The journal does not publish case reports.
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