Short stature is a risk factor for heart transplant morbidity and mortality.

IF 0.7 Q3 Medicine

ASIAN CARDIOVASCULAR & THORACIC ANNALS Pub Date : 2023-10-01 Epub Date: 2023-09-04 DOI:10.1177/02184923231197691

Noah Weingarten, Amit Iyengar, Mrinal Patel, Samuel T Kim, Max Shin, Pavan Atluri

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引用次数: 0

Abstract

Background: Short stature is associated with mortality after cardiac surgery and may increase size mismatch risk among transplant recipients. Yet, stature's impact on heart transplant outcomes is not well-characterized.

Methods: The Scientific Registry of Transplant Recipients was queried for data on all adult heart transplants in the United States from 2000 to 2022. Recipients were stratified into five cohorts by sex-corrected stature. Morbidity was assessed with Kruskal-Wallis and chi-squared tests. Mortality was analyzed using Kaplan-Meier estimation. Risk factors for mortality were assessed with multivariable Cox regression.

Results: Among 43,420 transplant recipients, 5321 (12.2%) had short stature (females >4'11″ & ≤5'1″; males >5'4″ & ≤5'7″) and 765 (1.8%) had very short stature (females ≤4'11″; males ≤5'4″). Very short stature patients had higher waitlist status (1A and 1), more congenital heart disease, and received more oversized donor hearts than other cohorts (all p < 0.05). Very short stature patients had decreased 30-day, 1-, 5-, and 10-year survival (94.6%, 84.3%, 69.3% and 52.5%, respectively, all p < 0.001), but less acute rejection (p = 0.005) and comparable stroke rates (p = 0.107). On multivariable regression adjusting for congenital heart disease and oversized donor hearts, very short and short stature were associated with 10-year mortality (hazard ratios: 1.40 and 1.12, respectively, both p < 0.005).

Conclusions: Short stature confers increased mortality risk for heart transplant recipients and merits inclusion in prognostic models.

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身材矮小是心脏移植发病率和死亡率的一个危险因素。

背景：身材矮小与心脏手术后的死亡率有关，并可能增加移植受者的体型不匹配风险。然而，身材对心脏移植结果的影响并没有得到很好的描述。方法：向移植接受者科学登记处查询2000年至2022年美国所有成人心脏移植的数据。受试者按性别校正身高分为五组。使用Kruskal-Wallis和卡方检验评估发病率。死亡率采用Kaplan-Meier估计进行分析。死亡率的危险因素采用多变量Cox回归进行评估。结果：在43420名移植受者中，5321人（12.2%）身材矮小（女性>4'11〃&≤5'1〃；男性>5'4〃&≤5'7〃），765人（1.8%）身材极短（女性≤4'11〃；男性≤5'4〃）。与其他队列相比，身材矮小的患者有更高的等待名单状态（1A和1），更多的先天性心脏病，并接受了更多的超大供体心脏（均p p p = 0.005）和可比较的中风率（p = 0.107）。在校正先天性心脏病和超大供体心脏的多变量回归分析中，身材极短和矮小与10年死亡率相关（危险比分别为1.40和1.12，两者均为p 结论：身材矮小会增加心脏移植受者的死亡率，值得纳入预后模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ASIAN CARDIOVASCULAR & THORACIC ANNALS Multiple-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The Asian Cardiovascular and Thoracic Annals is an international peer-reviewed journal pertaining to cardiovascular and thoracic medicine. Besides original clinical manuscripts, we welcome research reports, product reviews, reports of new techniques, and findings of special significance to Asia and the Pacific Rim. Case studies that have significant novel original observations, are instructive, include adequate methodological details and provide conclusions. Workshop proceedings, meetings and book reviews, letters to the editor, and meeting announcements are encouraged along with relevant articles from authors.