Prognostic value of preoperative serological biomarkers in patients undergoing cytoreductive surgery for ovarian cancer peritoneal metastases.

IF 1.4 Q4 ONCOLOGY

Pleura and Peritoneum Pub Date : 2023-09-01 DOI:10.1515/pp-2022-0199

Charif Khaled, Antoine El Asmar, Omar Raisi, Michel Moreau, Laura Polastro, Isabelle Veys, Florin C Pop, Vincent Donckier, Gabriel Liberale

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引用次数: 1

Abstract

Objectives: Peritoneal metastases of ovarian cancer (PMOC) are common at initial presentation. Cytoreductive surgery (CRS) of curative intent has been proven to be efficient in increasing the overall survival (OS) and the disease-free survival (DFS) of these patients. Nevertheless, CRS is associated with high postoperative morbidity, which makes patient selection a major concern. Appropriate prognostic factors that can predict patient outcomes after surgery are still lacking. Preoperative biomarkers and their ratios have been shown to be predictive of patient prognosis for various solid tumors. We aimed to study their correlation with the prognosis of patients undergoing CRS for PMOC.

Methods: This retrospective study included patients with PMOC operated by CRS. Preoperative biomarkers and other clinicopathological characteristics were studied to determine their prognostic value in terms OS and DFS.

Results: 216 patients were included. Patients with preoperative hemoglobin (Hb) <11.7 g/dL had a poorer prognosis in terms of OS (p=0.0062) and DFS (p=0.0077). Additionally, increased neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) >0.32, and platelet-to-lymphocyte ratio (PLR) >214.5 were associated with worse OS (p=0.022, p=0.0028, and p=0.0018, respectively) and worse DFS (p=0.028, p=0.003, and p=0.019, respectively). Multivariate analysis showed that the variables mentioned above were independent predictive factors for OS and DFS.

Conclusions: Preoperative Hb level, NLR, MLR, and PLR are prognostic factors for OS and DFS in PMOC patients operated by curative CRS.

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术前血清学生物标志物在卵巢癌腹膜转移患者行细胞减缩手术中的预后价值。

目的:卵巢癌腹膜转移(PMOC)在最初的表现是常见的。具有治疗目的的细胞减少手术(CRS)已被证明可有效提高这些患者的总生存期(OS)和无病生存期(DFS)。然而，CRS与术后高发病率相关，这使得患者选择成为一个主要问题。目前仍缺乏能够预测手术后患者预后的适当预后因素。术前生物标志物及其比值已被证明可以预测各种实体瘤的预后。我们的目的是研究它们与PMOC患者接受CRS的预后的相关性。方法:回顾性研究采用CRS手术的PMOC患者。研究术前生物标志物和其他临床病理特征，以确定其在OS和DFS方面的预后价值。结果:共纳入216例患者。术前血红蛋白(Hb) 0.32、血小板与淋巴细胞比值(PLR) >214.5的患者，OS加重(p=0.022、p=0.0028、p=0.0018)， DFS加重(p=0.028、p=0.003、p=0.019)。多因素分析表明，上述变量是OS和DFS的独立预测因素。结论:术前Hb水平、NLR、MLR和PLR是治疗性CRS手术PMOC患者OS和DFS的预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pleura and Peritoneum Multiple-

CiteScore

2.50

自引率

11.10%

发文量

审稿时长

9 weeks