Childhood asthma phenotypes and endotypes: a glance into the mosaic.

IF 2.4 Q1 PEDIATRICS
Francesco Foppiano, Bianca Schaub
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引用次数: 0

Abstract

Background: Asthma is an inflammatory lung disease that constitutes the most common noncommunicable chronic disease in childhood. Childhood asthma shows large heterogeneity regarding onset of disease, symptoms, severity, prognosis, and response to therapy.

Main body: Evidence suggests that this variability is due to distinct pathophysiological mechanisms, which has led to an exhaustive research effort to understand and characterize these distinct entities currently designated as "endotypes." Initially, studies focused on identifying specific groups using clinical variables yielding different "clinical phenotypes." In addition, the identification of specific patterns based on inflammatory cell counts and cytokine data has resulted in "inflammatory endotypes." More recently, an increasing number of molecular data from high-throughput technology ("omics" data) have allowed to investigate more complex "molecular endotypes."

Conclusion: A better definition and comprehension of childhood asthma heterogeneity is key for improving diagnosis and treatment. This review aims at summarizing the current knowledge on this topic and discusses some limitations in their application as well as recommendations for future studies.

Abstract Image

儿童哮喘表型和内型:一瞥进入马赛克。
背景:哮喘是一种炎症性肺部疾病,是儿童时期最常见的非传染性慢性疾病。儿童哮喘在发病、症状、严重程度、预后和治疗反应方面表现出很大的异质性。正文:有证据表明,这种可变性是由于不同的病理生理机制,这导致了详尽的研究努力来理解和表征这些不同的实体,目前被称为“内源性”。最初,研究集中于使用产生不同“临床表型”的临床变量来识别特定的群体。此外,基于炎症细胞计数和细胞因子数据的特定模式的识别导致了“炎症内型”。最近,越来越多来自高通量技术的分子数据(“组学”数据)允许研究更复杂的“分子内型”。结论:更好地定义和理解儿童哮喘异质性是提高诊断和治疗水平的关键。本文综述了目前关于这一课题的知识,并讨论了其应用中的一些局限性以及对未来研究的建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
2.20
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