Impact of therapeutic and low volume plasma exchange on clinical laboratory parameters in patients treated for Alzheimer's disease from the AMBAR study.

IF 1.5 4区医学 Q3 HEMATOLOGY

Therapeutic Apheresis and Dialysis Pub Date : 2023-10-01 Epub Date: 2023-05-21 DOI:10.1111/1744-9987.14002

Carlota Grifols, Miquel Barceló, Laura Núñez, Zbigniew M Szczepiorkowski, Mercè Boada, Oscar L López, Antonio Páez

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引用次数: 0

Abstract

Introduction: Little is known about the impact of plasma exchange (PE) on clinical laboratory parameters in Alzheimer's disease (AD) patients.

Methods: AD patients in the AMBAR trial (N = 322) received weekly therapeutic PE (TPE) for 6 weeks followed by monthly low-volume PE (LVPE) for12 months. Treatment were placebo (sham PE), low-albumin, low-albumin + IVIG (i.e., albumin alternated with intravenous immunoglobulin) and high-albumin + IVIG.

Results: Coagulation parameters transiently increased post-TPE. Blood calcium, platelets, and albumin levels decreased but remained within the reference range. Leukocyte counts increased. Fibrinogen, hemoglobin, total protein, gamma globulin, and IgG, transiently dipped below the reference range. Hypogammaglobulinemia (7.2 g/L) persisted in pre-TPE measurements. No changes were observed during the LVPE period. Cerebrospinal fluid parameters and vital signs were unchanged throughout.

Conclusion: Laboratory parameters of AD patients were affected by TPE similarly to effects of PE-treatment for other pathologies. These effects were less pronounced or non-existent for LVPE.

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AMBAR研究中治疗性和低容量血浆交换对阿尔茨海默病患者临床实验室参数的影响。

引言：人们对血浆交换（PE）对阿尔茨海默病（AD）患者临床实验室参数的影响知之甚少。方法：在AMBAR试验中AD患者（N = 322）接受每周治疗性PE（TPE）6 周后每月低容量PE（LVPE）12 月。治疗为安慰剂（假PE）、低白蛋白、低白蛋白 + IVIG（即白蛋白与静脉注射免疫球蛋白交替）和高白蛋白 + IVIG。结果：TPE后凝血参数瞬时增加。血钙、血小板和白蛋白水平下降，但仍在参考范围内。白细胞计数增加。纤维蛋白原、血红蛋白、总蛋白、丙种球蛋白和IgG暂时低于参考范围。低丙种球蛋白血症（7.2 g/L）。LVPE期间未观察到任何变化。脑脊液参数和生命体征始终没有变化。结论：TPE对AD患者的实验室参数的影响与PE治疗其他疾病的影响相似。LVPE的这些影响不太明显或根本不存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Apheresis and Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

10.50%

发文量

166

审稿时长

6-12 weeks

期刊介绍： Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.