Cost-effectiveness of extended DPYD testing before fluoropyrimidine chemotherapy in metastatic breast cancer in the UK.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-07-01 Epub Date: 2023-09-04 DOI:10.2217/pme-2022-0099

Rositsa Koleva-Kolarova, Heleen Vellekoop, Simone Huygens, Matthijs Versteegh, Maureen Rutten-van Mölken, László Szilberhorn, Tamás Zelei, Balázs Nagy, Sarah Wordsworth, Apostolos Tsiachristas

引用次数: 2

Abstract

The aim of this study was to evaluate the cost-effectiveness of ToxNav^©, a multivariant genetic test, to screen for DPYD followed by personalized chemotherapy dosing for metastatic breast cancer in the UK compared with no testing followed by standard dose, standard of care. In the main analysis, ToxNav was dominant over standard of care, producing 0.19 additional quality-adjusted life years and savings of £78,000 per patient over a lifetime. The mean additional quality-adjusted life years per person from 1000 simulations was 0.23 savings (95% CI: 0.22-0.24) at £99,000 (95% CI: £95-102,000). Varying input parameters independently by range of 20% was unlikely to change the results in the main analysis. The probabilistic sensitivity analysis showed ~97% probability of the ToxNav strategy to be dominant.

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英国癌症转移性乳腺癌氟嘧啶化疗前延长DPYD试验的成本效益。

本研究的目的是评估ToxNav©（一种多变量基因测试）的成本效益，以筛选英国转移性乳腺癌症的DPYD，然后进行个性化化疗剂量，与未进行测试，然后进行标准剂量、标准护理相比。在主要分析中，ToxNav在标准护理中占主导地位，为每位患者带来了0.19个额外的质量调整生命年，并在一生中节省了78000英镑。从1000次模拟中，每人平均额外的质量调整寿命为0.23年（95%置信区间：0.22-0.24），为99000英镑（95%置信度：95-102000英镑）。在20%的范围内独立改变输入参数不太可能改变主分析的结果。概率敏感性分析显示ToxNav策略占主导地位的概率约为97%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.