Jennifer A Deal, Kening Jiang, Andreea Rawlings, A Richey Sharrett, Nicholas S Reed, David Knopman, Thomas Mosley, Dean Wong, Yun Zhou, Frank R Lin, Rebecca F Gottesman
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引用次数: 0
Abstract
Background: Hearing loss is a risk factor for dementia; whether the association is causal or due to a shared pathology is unknown. We estimated the association of brain β-amyloid with hearing, hypothesizing no association. As a positive control, we quantified the association of hearing loss with neurocognitive test performance.
Methods: Cross-sectional analysis of Atherosclerosis Risk in Communities-Positron Emission Tomography study data. Amyloid was measured using global cortical and temporal lobe standardized uptake value ratios (SUVRs) calculated from florbetapir-positron emission tomography scans. Composite global and domain-specific cognitive scores were created from 10 neurocognitive tests. Hearing was measured using an average of better-ear air conduction thresholds (0.5-4 kHz). Multivariable-adjusted linear regression estimated mean differences in hearing by amyloid and mean differences in cognitive scores by hearing, stratified by race.
Results: In 252 dementia-free adults (72-92 years, 37% Black race, and 61% female participants), cortical or temporal lobe SUVR was not associated with hearing (models adjusted for age, sex, education, and APOE ε4). Each 10 dB HL increase in hearing loss was associated with a 0.134 standard deviation lower mean global cognitive factor score (95% CI: -0.248, -0.019), after adjustment for demographic and cardiovascular factors. Observed hearing-cognition associations were stronger in Black versus White participants.
Conclusions: Amyloid is not associated with hearing, suggesting that pathways linking hearing and cognition are independent of this pathognomonic Alzheimer's-related brain change. This is the first study to show that the impact of hearing loss on cognition may be stronger in Black versus White adults.
背景：听力损失是痴呆症的一个危险因素；这种关联是因果关系还是由于共同的病理学尚不清楚。我们估计了大脑β-淀粉样蛋白与听力的关系，假设没有关联。作为阳性对照，我们量化了听力损失与神经认知测试表现的关系。方法：横断面分析社区动脉粥样硬化风险的正电子发射断层扫描研究数据。淀粉样蛋白的测量使用全皮质和颞叶标准化摄取值比率（SUVRs），该比率是根据氟倍他吡正电子发射断层扫描计算的。从10项神经认知测试中得出综合的全局和特定领域认知得分。使用较好的耳朵空气传导阈值（0.5-4kHz）的平均值来测量听力。多变量调整线性回归估计了淀粉样蛋白的听力平均差异和按种族分层的听力认知评分的平均差异。结果：在252名无痴呆症的成年人（72-92岁，37%的黑人，61%的女性参与者）中，皮层或颞叶SUVR与听力无关（模型根据年龄、性别、教育程度和APOEε4进行了调整）。在对人口统计学和心血管因素进行调整后，听力损失每增加10 dB HL，平均全球认知因素得分就会降低0.134标准差（95%CI:-0.248，-0.019）。观察到的听力认知关联在黑人和白人参与者中更强。结论：淀粉样蛋白与听力无关，这表明连接听力和认知的途径与阿尔茨海默氏症相关的大脑变化无关。这是第一项表明听力损失对认知的影响在黑人成年人中可能比白人成年人更强的研究。
期刊介绍：
Publishes articles representing the full range of medical sciences pertaining to aging. Appropriate areas include, but are not limited to, basic medical science, clinical epidemiology, clinical research, and health services research for professions such as medicine, dentistry, allied health sciences, and nursing. It publishes articles on research pertinent to human biology and disease.
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