An assembly of TROP2-mediated signaling events

IF 3.6 3区生物学 Q3 CELL BIOLOGY

Journal of Cell Communication and Signaling Pub Date : 2023-04-04 DOI:10.1007/s12079-023-00742-1

Shubham Sukerndeo Upadhyay, Rex Devasahayam Arokia Balaya, Sakshi Sanjay Parate, Shobha Dagamajalu, T. S. Keshava Prasad, Rohan Shetty, Rajesh Raju

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引用次数: 0

Abstract

Trophoblast cell surface antigen 2 (TROP2) is a calcium-transducing transmembrane protein mainly involved in embryo development. The aberrant expression of TROP2 is observed in numerous cancers, including triple-negative breast cancer, gastric, colorectal, pancreatic, squamous cell carcinoma of the oral cavity, and prostate cancers. The main signaling pathways mediated by TROP2 are calcium signaling, PI3K/AKT, JAK/STAT, MAPKs, and β-catenin signaling. However, collective information about the TROP2-mediated signaling pathway is not available for visualization or analysis. In this study, we constructed a TROP2 signaling map with respect to its role in different cancers. The data curation was done manually by following the NetPath annotation criteria. The described map consists of different molecular events, including 8 activation/inhibition, 16 enzyme catalysis, 19 gene regulations, 12 molecular associations, 39 induced-protein expressions, and 2 protein translocation. The data of the TROP2 pathway map is made freely accessible through the WikiPathways Database (https://www.wikipathways.org/index.php/Pathway:WP5300).

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trop2介导的信号事件的集合

滋养细胞表面抗原2 (Trophoblast cell surface antigen 2, TROP2)是一种钙转导跨膜蛋白，主要参与胚胎发育。TROP2在许多癌症中都有异常表达，包括三阴性乳腺癌、胃癌、结肠直肠癌、胰腺癌、口腔鳞状细胞癌和前列腺癌。TROP2介导的主要信号通路有钙信号、PI3K/AKT、JAK/STAT、MAPKs和β-catenin信号。然而，关于trop2介导的信号通路的集体信息无法用于可视化或分析。在本研究中，我们构建了TROP2在不同癌症中的作用的信号图谱。数据管理是通过遵循NetPath注释标准手动完成的。所描述的图谱包含不同的分子事件，包括8个激活/抑制，16个酶催化，19个基因调控，12个分子关联，39个诱导蛋白表达和2个蛋白易位。TROP2通路图的数据可以通过WikiPathways数据库(https://www.wikipathways.org/index.php/Pathway:WP5300)免费获取。

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来源期刊

Journal of Cell Communication and Signaling CELL BIOLOGY-

CiteScore

6.40

自引率

4.90%

发文量

期刊介绍： The Journal of Cell Communication and Signaling provides a forum for fundamental and translational research. In particular, it publishes papers discussing intercellular and intracellular signaling pathways that are particularly important to understand how cells interact with each other and with the surrounding environment, and how cellular behavior contributes to pathological states. JCCS encourages the submission of research manuscripts, timely reviews and short commentaries discussing recent publications, key developments and controversies. Research manuscripts can be published under two different sections : In the Pathology and Translational Research Section (Section Editor Andrew Leask) , manuscripts report original research dealing with celllular aspects of normal and pathological signaling and communication, with a particular interest in translational research. In the Molecular Signaling Section (Section Editor Satoshi Kubota) manuscripts report original signaling research performed at molecular levels with a particular interest in the functions of intracellular and membrane components involved in cell signaling.