Human Papillomavirus-Related Carcinomas of the Sinonasal Tract.

IF 0.4 Q4 OTORHINOLARYNGOLOGY

Current Otorhinolaryngology Reports Pub Date : 2022-09-01 DOI:10.1007/s40136-022-00404-7

Diana C Lopez, Austin T K Hoke, Lisa M Rooper, Nyall R London

{"title":"Human Papillomavirus-Related Carcinomas of the Sinonasal Tract.","authors":"Diana C Lopez, Austin T K Hoke, Lisa M Rooper, Nyall R London","doi":"10.1007/s40136-022-00404-7","DOIUrl":null,"url":null,"abstract":"Purpose of review: The sinonasal tract is home to a uniquely heterogenous collection of malignant tumors. Human papillomavirus (HPV) has been detected in a number of these, but the virus' role as an oncogenic driver or coincidental finding remains unclear. We aim to highlight five sinonasal tumor types and synthesize the prevalence, etiologic role, and known clinicopathologic relevance of HPV in each.Recent findings: The last decade has seen an expansion of investigation into HPV's oncogenic and prognostic significance within sinonasal malignancies. The sinonasal tract poses challenges to HPV detection where p16 lacks value as an accurate surrogate. A growing body of data supports a potentially favorable clinical profile for certain sinonasal HPV-positive lesions.Summary: HPV represents a potential biologically and clinically relevant factor for some sinonasal malignancies. Definitive conclusions regarding HPV's role as a potential oncogenic agent require routine testing using validated methodologies, genomic interrogation, and large-scale prospective studies.","PeriodicalId":36165,"journal":{"name":"Current Otorhinolaryngology Reports","volume":"10 ","pages":"291-302"},"PeriodicalIF":0.4000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610077/pdf/nihms-1808961.pdf","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Otorhinolaryngology Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40136-022-00404-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 4

Abstract

Purpose of review: The sinonasal tract is home to a uniquely heterogenous collection of malignant tumors. Human papillomavirus (HPV) has been detected in a number of these, but the virus' role as an oncogenic driver or coincidental finding remains unclear. We aim to highlight five sinonasal tumor types and synthesize the prevalence, etiologic role, and known clinicopathologic relevance of HPV in each.

Recent findings: The last decade has seen an expansion of investigation into HPV's oncogenic and prognostic significance within sinonasal malignancies. The sinonasal tract poses challenges to HPV detection where p16 lacks value as an accurate surrogate. A growing body of data supports a potentially favorable clinical profile for certain sinonasal HPV-positive lesions.

Summary: HPV represents a potential biologically and clinically relevant factor for some sinonasal malignancies. Definitive conclusions regarding HPV's role as a potential oncogenic agent require routine testing using validated methodologies, genomic interrogation, and large-scale prospective studies.

查看原文本刊更多论文

人乳头状瘤病毒相关的鼻窦炎。

回顾的目的:鼻道是一个独特的异质收集恶性肿瘤的家。人类乳头瘤病毒(HPV)已经在其中的一些病例中被检测到，但该病毒作为致癌驱动因素的作用或巧合发现仍不清楚。我们的目标是强调五种鼻窦肿瘤类型，并综合HPV在每种类型中的患病率，病因学作用和已知的临床病理相关性。最近的发现:在过去的十年中，人们对HPV在鼻窦恶性肿瘤中的致癌和预后意义进行了广泛的研究。鼻腔对HPV检测提出了挑战，其中p16缺乏作为准确替代品的价值。越来越多的数据支持某些鼻腔hpv阳性病变的潜在有利临床特征。摘要:HPV代表了一些鼻窦恶性肿瘤的潜在生物学和临床相关因素。关于HPV作为潜在致癌因子的作用的明确结论需要使用有效的方法进行常规测试，基因组询问和大规模前瞻性研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Otorhinolaryngology Reports Medicine-Surgery

CiteScore

1.00

自引率

16.70%

发文量

期刊介绍： This journal aims to offer expert review articles on the most significant recent developments in the field of otorhinolaryngology. By providing clear, insightful, balanced contributions, the journal intends to serve all those involved in the diagnosis and treatment of ear, nose, throat, and head and neck disorders. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include chronic rhinosinusitis; implantable devices; neurolaryngology; otolaryngic allergy; robotic surgery; sleep apnea; skull base surgery; thyroid surgery; and quality and outcomes.