Association Between Idiopathic Thrombocytopenic Purpura and Hemorrhagic and Nonhemorrhagic Stroke.

Q3 Medicine

Critical Pathways in Cardiology Pub Date : 2024-03-01 Epub Date: 2023-08-25 DOI:10.1097/HPC.0000000000000332

Rachna Guntu, Aamir Patel, Mohammad Reza Movahed, Mehrtash Hashemzadeh, Mehrnoosh Hashemzadeh

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引用次数: 0

Abstract

Background: Idiopathic thrombocytopenic purpura (ITP) is characterized by a low platelet count. This may lead to an increased risk of hemorrhagic stroke but a lower rate of nonhemorrhagic stroke. The goal of this study was to evaluate the association between ITP and both hemorrhagic and nonhemorrhagic strokes using a large database.

Methods: We used the Nationwide Inpatient Sample (NIS) database to analyze the occurrence of hemorrhagic and nonhemorrhagic stroke in patients with and without a diagnosis of ITP from 2005 to 2014.

Results: Univariate analysis revealed a higher incidence of hemorrhagic stroke in patients with ITP in the year studied. (for example, in 2005: OR, 1.75; 95% CI, 1.57-1.94; P < 0.001; 2014: OR, 2.19; 95% CI, 2.03-2.36; P < 0.001). After adjusting for age, gender, race, and hypertension, hemorrhagic stroke remained significantly associated with ITP (in 2005: OR, 1.85; 95% CI, 1.49-1.89; P < 0.001; 2014: OR, 2.01; 95% CI, 1.86-2.18; P < 0.001) for all the years studied. Nonhemorrhagic stroke occurred at a lower rate in patients with ITP in most years (2006: OR, 0.91; 95% CI, 0.85-0.97; P = 0.004; 2014: OR, 0.88; 95% CI, 0.83-0.93; P < 0.001). Multivariate analysis confirmed a higher rate of nonhemorrhagic stroke in ITP patients.

Conclusion: Our analysis showed that there was a higher rate of hemorrhagic stroke but a lower rate of ischemic stroke in ITP patients, suggesting an important role of platelets in the occurrence of stroke.

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特发性血小板减少性紫癜与出血性和非出血性中风之间的关系

背景：特发性血小板减少性紫癜（ITP特发性血小板减少性紫癜（ITP）的特点是血小板计数低。这可能导致出血性中风的风险增加，但非出血性中风的发生率较低。本研究的目的是利用大型数据库评估 ITP 与出血性和非出血性脑卒中之间的关联：我们使用全国住院病人抽样（NIS）数据库，分析了 2005 年至 2014 年期间诊断为和未诊断为 ITP 的患者发生出血性和非出血性脑卒中的情况：结果：单变量分析显示，在所研究的年份中，ITP患者出血性中风的发病率较高。(例如，在 2005 年，出血性脑卒中的发病率为 1.75，而在 2014 年为 1.75：或，1.75；95% CI，1.57-1.94；P <0.001；2014 年：或，2.19；95% CI，2.03-2.36；P <0.001）。在对年龄、性别、种族和高血压进行调整后，出血性脑卒中与 ITP 仍有显著相关性（2005 年：或，1.85；95% CI；2014 年：或，2.36；P < 0.001）：OR，1.85；95% CI，1.49-1.89；P <0.001；2014 年：OR，2.01；95% CI，1.86-2.18；P <0.001）。在大多数年份中，ITP 患者非出血性中风的发生率较低（2006 年：OR，0.91；95% CI，1.86-2.18；P<0.001）：或，0.91；95% CI，0.85-0.97；P = 0.004；2014 年：或，0.88；95% CI，0.83-0.93；P <0.001）。多变量分析证实，ITP 患者的非出血性中风发生率更高：我们的分析表明，ITP 患者出血性中风的发生率较高，但缺血性中风的发生率较低，这表明血小板在中风的发生中起着重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Pathways in Cardiology Medicine-Medicine (all)

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Critical Pathways in Cardiology provides a single source for the diagnostic and therapeutic protocols in use at hospitals worldwide for patients with cardiac disorders. The Journal presents critical pathways for specific diagnoses—complete with evidence-based rationales—and also publishes studies of these protocols" effectiveness.