Effect of supplementation with Saccharomyces boulardii CNCM I-1079 on vaccine response to an inactivated bacterial vaccine in young Japanese Black calves: A field trial.

IF 1.1 4区农林科学 Q2 Veterinary

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Pub Date : 2023-07-01

Kazusa Mori, Asato Uchiumi, Kai Yamamoto, Yuki Shimizu, Risa Ueda, Keigo Kosenda, Tomochika Fukuhara, Syunsuke Kure, Hiroyuki Fukazawa, Hiromichi Ohtsuka

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引用次数: 0

Abstract

Saccharomyces boulardii group (SB group) calves were fed 2.0 × 10¹⁰ CFU/day of S. boulardii in milk replacer after 2 wk of age. All calves received inactivated vaccine for Histophilus somni, Pasteurella multocida, and Mannheimia haemolytica at 3 wk of age and 3 wk later. After vaccination, the SB group calves showed significantly higher (mean difference: 1.56-fold) antibody titer against H. somni than the control group. The number of calves with the antibody titer above the cut-off value for M. haemolytica of the SB group was significantly higher than that of the control, and the percentage was twice as high. In addition, the mRNA transcription of IL4 and IL10 in peripheral blood mononuclear cells at the booster of the SB group was significantly higher than those of the control. In conclusion, S. boulardii may have positively affected immune responses to the inactivated multi-bacterial vaccine in young calves in the field.

本刊更多论文

补充博氏酵母CNCM I-1079对日本黑犊牛对一种灭活细菌疫苗反应的影响:一项田间试验

博氏酵母菌组(SB组)犊牛2周龄后在代乳饲料中添加2.0 × 1010 CFU/d的博氏酵母菌。所有犊牛在3周龄和3周龄后分别接种嗜睡组织菌、多杀性巴氏杆菌和溶血性曼海默病灭活疫苗。接种后，SB组犊牛的抗血吸虫抗体效价显著高于对照组(平均差异为1.56倍)。血清SB组溶血支原体抗体效价高于临界值的犊牛数量显著高于对照组，比例是对照组的2倍。此外，SB增强组外周血单个核细胞中IL4和IL10 mRNA转录量显著高于对照组。综上所述，博拉氏沙门氏菌可能对小牛对多细菌灭活疫苗的免疫反应有积极影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 农林科学-兽医学

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

>24 weeks

期刊介绍： The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.