Effect of Transcranial Pulse Stimulation for the Treatment of Alzheimer´s Disease and its Related Symptoms.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Current Alzheimer research Pub Date : 2023-01-01 DOI:10.2174/1567205020666230727102025

Ramiro Fernández-Castaño, Miguel Ángel Fernández-Blázquez, Iria Echevarría-Fernández, Manuela Cabrera-Freitag, Karin Freitag

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引用次数: 0

Abstract

Alzheimer's disease (AD) is the most common cause of neurodegenerative cognitive impairment. Brain stimulation techniques based on the delivery of transcranial shockwaves are currently being studied for their increasing popularity as an approach to modulate the human brain in a focal and targeted manner making this therapy a promising line of action against AD. In the present manuscript, we review for further understanding whether transcranial pulse stimulation (TPS) is a beneficial treatment for AD patients. PubMed, Google Scholar, and Cochrane databases were accessed with the search criteria set from year 2001 to 2022 and the following keywords were used: "transcranial pulse stimulation", "focused ultrasound", "noninvasive treatment and Alzheimer" and "TPS". The search was focused on papers that provide evidence on the biological bases of the method, as well as its safety and tolerability. Even though more studies are needed with greater scientific rigor, such as a doubleblind and randomized study versus a placebo, TPS is an excellent and safe therapeutic option for AD. This novel approach accompanies currently available treatments and complements them, helping to maintain greater stability of the disease and slowing its progression. The biological effects and potential mechanisms of action of TPS for the improvement of cognitive function are further discussed.

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经颅脉冲刺激治疗阿尔茨海默病及其相关症状的效果。

阿尔茨海默病(AD)是神经退行性认知障碍的最常见原因。基于经颅冲击波传递的脑刺激技术目前正在研究中，因为它们越来越受欢迎，作为一种以局部和有针对性的方式调节人类大脑的方法，使这种治疗成为对抗AD的有希望的行动路线。在本文中，我们回顾以进一步了解经颅脉冲刺激(TPS)是否对AD患者有益。检索标准为2001 - 2022年的PubMed、Google Scholar和Cochrane数据库，使用的关键词为:“经颅脉冲刺激”、“聚焦超声”、“无创治疗和阿尔茨海默病”和“TPS”。搜索的重点是提供该方法生物学基础证据的论文，以及它的安全性和耐受性。尽管需要更多的科学严谨的研究，如双盲和随机研究与安慰剂相比，TPS是一个很好的和安全的治疗AD的选择。这种新方法伴随着现有的治疗方法并对其进行补充，有助于保持疾病的更大稳定性并减缓其进展。进一步探讨了TPS在改善认知功能方面的生物学效应和可能的作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Alzheimer research 医学-神经科学

CiteScore

4.00

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.