Comparative Evaluation of Matrix Metalloproteinase-9 Immunoassay and Tear Osmolarity Measurement for Diagnosing Severity of Dry Eye Disease.

Q3 Medicine
Korean Journal of Ophthalmology : KJO Pub Date : 2023-10-01 Epub Date: 2023-08-25 DOI:10.3341/kjo.2023.0062
Moonjung Choi, Young Min Park, Byung Yi Ko
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引用次数: 1

Abstract

Purpose: To evaluate and compare the clinical efficacy of matrix metalloproteinase-9 (MMP-9) immunoassay and tear osmolarity measurement in diagnosing dry eye severity.

Methods: Dry eye disease (DED) patients underwent diagnostic tests including MMP-9 assay, tear osmolarity measurement, fluorescein tear breakup time, ocular surface staining, anesthetized Schirmer test, Ocular Surface Disease Index questionnaire, and slit-lamp examination. The dry eye parameters were compared according to positive MMP-9 status and increased tear osmolarity. The correlation between dry eye profiles and MMP-9 positivity and high tear osmolarity was also analyzed.

Results: Those who tested positive in MMP-9 immunoassay had significantly higher corneal fluorescein staining score and worse DED severity than those who tested negative. The intensity of MMP-9 positivity showed positive correlation with the corneal staining score and DED severity. However, DED patients with high tear osmolarity above 308 mOsm/L did not show significantly different dry eye signs and symptoms compared to those with lower tear osmolarity values. Tear osmolarity was associated with ocular surface staining score in severe DED patients.

Conclusions: MMP-9 positivity was associated with ocular surface staining and worse dry eye severity. Therefore, it may be used as a useful indicator of disease severity in conjunction to other diagnostic tests.

Abstract Image

Abstract Image

基质金属蛋白酶-9免疫测定法和泪液渗透性测定法诊断干眼病严重程度的比较评价。
目的:评价和比较基质金属蛋白酶-9(MMP-9)免疫测定和泪液渗透压测定在诊断干眼症严重程度中的临床疗效。方法:对干眼病(DED)患者进行诊断测试,包括MMP-9测定、泪液渗透压测定、荧光素泪液破裂时间、眼表染色、麻醉Schirmer试验、眼表疾病指数问卷和裂隙灯检查。根据MMP-9阳性状态和增加的泪液渗透压比较干眼参数。还分析了干眼特征与MMP-9阳性和高泪液渗透压之间的相关性。结果:MMP-9免疫测定阳性者角膜荧光素染色评分显著高于阴性者,DED严重程度较阴性者差。MMP-9阳性强度与角膜染色评分和DED严重程度呈正相关。然而,与泪液渗透压值较低的DED患者相比,泪液渗透浓度高于308mOsm/L的DED病人没有表现出显著不同的干眼体征和症状。重度DED患者的泪液渗透压与眼表染色评分相关。结论:MMP-9阳性与眼表染色及干眼症加重有关。因此,它可以与其他诊断测试一起用作疾病严重程度的有用指标。
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来源期刊
Korean Journal of Ophthalmology : KJO
Korean Journal of Ophthalmology : KJO Medicine-Ophthalmology
CiteScore
2.40
自引率
0.00%
发文量
84
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