Prepregnancy body mass index and glycated albumin in the third trimester may predict infant complications in gestational diabetes mellitus: a retrospective cohort study.

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM

Diabetology International Pub Date : 2023-04-19 eCollection Date: 2023-07-01 DOI:10.1007/s13340-023-00631-3

Daisuke Sugawara, Eishi Makita, Misa Matsuura, Hiroaki Sato, Tomoyuki Kuwata, Ko Ichihashi

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引用次数: 0

Abstract

Background: Maternal hyperglycemia, obesity, and hypertension with gestational diabetes mellitus (GDM) are risk factors for infant complications. This study aimed to investigate maternal factors and glycemic control indicators that affect infant complications in GDM.

Methods: We conducted a retrospective cohort study including 112 mothers with GDM and their infants. Multivariate logistic regression analysis was used to investigate the variables associated with good and adverse infant outcomes. We determined the cutoff values of variables that showed a significant difference in the multivariate logistic regression analysis for predicting infant complications by performing receiver operating characteristic curve analysis.

Results: In the multivariate logistic regression analysis, prepregnancy BMI and GA in the third trimester were significantly related to good and adverse infant outcomes (adjusted odds ratios [aORs], 1.62; 95% CIs 1.17-2.25, p = 0.003 and aORs, 2.77; 95% CIs 1.15-6.64, p = 0.022, respectively). The cutoff values for prepregnancy BMI and GA in the third trimester were 25.3 kg/m2 and 13.5%, respectively.

Conclusions: The importance of weight control before pregnancy and the usefulness of GA in the third trimester to predict infant complications were suggested in this study.

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妊娠前体重指数和妊娠晚期糖化白蛋白可预测妊娠期糖尿病的婴儿并发症：一项回顾性队列研究。

背景：母亲高血糖、肥胖和高血压合并妊娠期糖尿病（GDM）是婴儿并发症的危险因素。本研究旨在调查影响GDM婴儿并发症的母亲因素和血糖控制指标。方法：我们对112名GDM母亲及其婴儿进行了回顾性队列研究。多变量逻辑回归分析用于研究与婴儿良好和不良结局相关的变量。我们通过进行受试者操作特征曲线分析，确定了在预测婴儿并发症的多变量逻辑回归分析中显示显著差异的变量的截止值。结果：在多变量逻辑回归分析中，孕晚期的孕前BMI和GA与婴儿的良好和不良结局显著相关（调整后的比值比[aORs]，1.62；95%CI 1.17-2.25，p = 0.003和aORs 2.77；95%置信区间1.15-6.64，p = 0.022）。妊娠前BMI和GA在妊娠晚期的临界值分别为25.3kg/m2和13.5%。结论：本研究提出了孕前体重控制的重要性以及孕晚期GA对预测婴儿并发症的有用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology International ENDOCRINOLOGY & METABOLISM-

CiteScore

3.90

自引率

4.50%

发文量

期刊介绍： Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.

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