Involvement of α- and β-Adrenergic Receptors in Skeletal Muscle Blood Flow Changes During Hyper-/Hypocapnia in Anesthetized Rabbits.

Q3 Medicine

Anesthesia progress Pub Date : 2023-06-01 DOI:10.2344/anpr-70-02-02

Kyotaro Koshika, Rumi Kaneko, Mai Shionoya, Kotaro Shimizu, Yuka Sendai, Nobutaka Matsuura, Yui Akiike, Tatsuya Ichinohe

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引用次数: 1

Abstract

Objective: This study investigated the involvement of α1- and β2-adrenergic receptors in skeletal muscle blood flow changes during variations in ETCO2.

Methods: Forty Japanese White rabbits anesthetized with isoflurane were randomly allocated to 1 of 5 groups: phentolamine, metaproterenol, phenylephrine, butoxamine, and atropine. Heart rate (HR), systolic blood pressure (SBP), common carotid artery blood flow (CCBF), masseter muscle tissue blood flow (MBF), and quadriceps muscle tissue blood flow (QBF) were recorded and analyzed at 3 periods: (1) baseline, (2) during hypercapnia (phentolamine and metaproterenol groups) or hypocapnia (phenylephrine, butoxamine, and atropine groups), and (3) during or after receiving vasoactive agents.

Results: MBF and QBF decreased during hypercapnia. The decrease in MBF was smaller than that in QBF. SBP and CCBF increased, while HR decreased. Both MBF and QBF recovered to their baseline levels after phentolamine administration. MBF became greater than its baseline level, while QBF did not fully recover after metaproterenol administration. MBF and QBF increased during hypocapnia. The increase rate in MBF was larger than that in QBF. HR, SBP, and CCBF did not change. Both MBF and QBF decreased to ∼90% to 95% of their baseline levels after phenylephrine or butoxamine administration. Atropine showed no effects on MBF and QBF.

Conclusion: These results suggest the skeletal muscle blood flow changes observed during hypercapnia and hypocapnia may mainly involve α1-adrenergic but not β2-adrenergic receptor activity.

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α-和β-肾上腺素能受体参与麻醉兔高/低碳酸血症时骨骼肌血流变化

目的:探讨α1-和β2-肾上腺素能受体在ETCO2变化时骨骼肌血流变化中的作用。方法:异氟醚麻醉的日本大白兔40只，随机分为酚妥拉明组、甲丙肾上腺素组、苯肾上腺素组、丁toxamine组和阿托品组。记录心率(HR)、收缩压(SBP)、颈总动脉血流量(CCBF)、咬肌组织血流量(MBF)和股四头肌组织血流量(QBF)在3个时间段进行分析:(1)基线;(2)高碳酸血症(酚妥拉明和甲丙肾上腺素组)或低碳酸血症(苯肾上腺素、丁氧胺和阿托品组);(3)接受血管活性药物期间或之后。结果:高碳酸血症时MBF和QBF降低。MBF的下降幅度小于QBF。收缩压和CCBF升高，HR降低。服用酚妥拉明后，MBF和QBF均恢复到基线水平。MBF大于基线水平，而给予甲丙肾上腺素后QBF没有完全恢复。低碳酸血症时MBF和QBF增加。MBF的增加幅度大于QBF。HR、SBP、CCBF无明显变化。给药后，MBF和QBF均降至基线水平的90% ~ 95%。阿托品对MBF和QBF无明显影响。结论:高碳酸血症和低碳酸血症时骨骼肌血流变化可能主要与α1-肾上腺素能受体活性有关，而与β2-肾上腺素能受体活性无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anesthesia progress Medicine-Medicine (all)

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Anesthesia Progress is a peer-reviewed journal and the official publication of the American Dental Society of Anesthesiology. The journal is dedicated to providing a better understanding of the advances being made in the art and science of pain and anxiety control in dentistry.