High baseline frequencies of natural killer cells are associated with asymptomatic SARS-CoV-2 infection

Q4 Immunology and Microbiology

Current research in immunology Pub Date : 2023-01-01 DOI:10.1016/j.crimmu.2023.100064

Elizabeth K. Graydon , Allison M.W. Malloy , Kawthar Machmach , Peifang Sun , Dominic Paquin-Proulx , Stephen Lizewski , Rhonda Lizewski , Dawn L. Weir , Carl W. Goforth , Stephen K. Anderson , Andrew G. Letizia , Edward Mitre

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引用次数: 1

Abstract

This study tested the hypothesis that high frequencies of natural killer (NK) cells are protective against symptomatic SARS-CoV-2 infection. Samples were utilized from the COVID-19 Health Action Response for Marines study, a prospective, observational study of SARS-CoV-2 infection in which participants were enrolled prior to infection and then serially monitored for development of symptomatic or asymptomatic infection. Frequencies and phenotypes of NK cells (CD3⁻CD14⁻CD19⁻CD56⁺) were assessed by flow cytometry. Individuals that developed asymptomatic infections were found to have higher pre-infection frequencies of total NK cells compared to symptomatic individuals (10.61% [SD 4.5] vs 8.33% [SD 4.6], p = 0.011). Circulating total NK cells decreased over the course of infection, reaching a nadir at 4 weeks, while immature NK cells increased, a finding confirmed by multidimensional reduction analysis. These results indicate that NK cells likely play a key role in controlling the severity of clinical illness in individuals infected with SARS-CoV-2.

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自然杀伤细胞的高基线频率与无症状的SARS-CoV-2感染有关

这项研究验证了一种假说，即高频率的自然杀伤细胞对有症状的严重急性呼吸系统综合征冠状病毒2型感染具有保护作用。样本来自新冠肺炎海军陆战队健康行动反应研究，这是一项针对SARS-CoV-2感染的前瞻性观察性研究，参与者在感染前登记，然后连续监测有症状或无症状感染的发展。通过流式细胞术评估NK细胞（CD3−CD14−CD19−CD56+）的频率和表型。与有症状的个体相比，出现无症状感染的个体在感染前的总NK细胞频率更高（10.61%[SD 4.5]vs 8.33%[SD 4.6]，p=0.011）。循环总NK细胞在感染过程中减少，在4周时达到最低点，而未成熟NK细胞增加，这一发现得到了多维还原分析的证实。这些结果表明，NK细胞可能在控制严重急性呼吸系统综合征冠状病毒2型感染者的临床疾病严重程度方面发挥关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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