Incidence and prevalence of alcoholic fatty liver disease: a prospective, community-based study among adult Sri Lankans.

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL
Madunil Anuk Niriella, Anuradhani Kasturiratne, Thulani Beddage, Shamila Thivanshi De Silva, Anuradha Dassanayake, Arunasalam Pathmeswaran, Ananda Rajitha Wickramasinghe, Norihiro Kato, Hithanadura Janaka De Silva
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引用次数: 0

Abstract

Background: Data on the alcoholic fatty liver (AFL) is limited. Therefore, we investigated alcohol use and AFL patterns among urban, adult Sri Lankans.

Methods: The study population (selected by age-stratified random sampling) was screened in 2007 (35-64 years) and re-evaluated in 2014. They were assessed by structured interviews, anthropometric measurements, liver-ultrasound, and biochemical and serological tests. AFL was diagnosed on ultrasound criteria, 'unsafe' alcohol consumption (Asian standards: males>14units, females>7units per week) and absence of hepatitis B/C markers. Controls were unsafe alcohol consumers who had no fatty liver on ultrasound.

Results: 2985/3012 (99%) had complete data for analysis. 272/2985 (9.1%) were unsafe-drinkers in 2007 [males-270; mean-age-51.9, SD-8.0 years]. 86/272 (31.6%) had AFL [males-85; mean-age-50.2, SD-8.6 years]. Males [p<0.001], increased waist circumference (WC) [OR 4.9, p<0.01] and BMI>23kg/m2 [OR 3.5, p<0.01] and raised alanine aminotransferase (ALT) [OR 2.8, p<0.01] were independently associated with AFL. 173/272 (63.6%) unsafe alcohol consumers from 2007 were re-evaluated in 2014. 134/173 had either had AFL or had changed to 'safe' or no alcohol consumption. 21/39 (53.8%) [males-21 (100%), mean-age-57.9, SD-7.9 years] who remained 'unsafe' alcohol users who had no fatty liver in 2007 developed AFL after 7-years (annual incidence 7.7%). On bivariate analysis, only males were associated with new-onset AFL. Of the 42 who had AFL at baseline but changed their drinking status from unsafe to safe or no alcohol, 6 had resolution of fatty liver in 2014.

Conclusion: In conclusion, in this community-based study among urban Sri Lankan adults, the annual incidence of AFL among unsafe alcohol users was 7.7%. Furthermore, new-onset AFL was associated with males.

酒精性脂肪性肝病的发病率和患病率:一项前瞻性、基于社区的斯里兰卡成年人研究
背景:关于酒精性脂肪肝(AFL)的数据有限。因此,我们调查了斯里兰卡城市成年人的酒精使用和AFL模式。方法:采用年龄分层随机抽样的方法,于2007年筛查35 ~ 64岁的研究人群,并于2014年进行重新评估。他们通过结构化访谈、人体测量、肝脏超声、生化和血清学测试进行评估。AFL的诊断是基于超声标准、“不安全”饮酒(亚洲标准:男性>14单位,女性>7单位每周)和没有乙型/丙型肝炎标志物。对照组为超声检查无脂肪肝的不安全饮酒者。结果:2985/3012(99%)有完整的分析资料。2007年,272/2985人(9.1%)为不安全饮酒者[男性270人;平均年龄51.9岁,SD-8.0岁]。86/272(31.6%)有AFL[男性85例;平均年龄50.2岁,SD-8.6岁]。结论:总之,在这项以社区为基础的斯里兰卡城市成年人研究中,不安全酒精使用者AFL的年发病率为7.7%。此外,新发AFL与男性相关。
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来源期刊
Ceylon Medical Journal
Ceylon Medical Journal MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
16
期刊介绍: The Ceylon Medical Journal, is the oldest surviving medical journal in Australasia. It is the only medical journal in Sri Lanka that is listed in the Index Medicus. The CMJ started life way back in 1887 as the organ of the Ceylon Branch of the British Medical Association. Except for a brief period between 1893 and 1904 when it ceased publication, the CMJ or its forbear, the Journal of the Ceylon Branch of the British Medical Association, has been published without interruption up to now. The journal"s name changed to the CMJ in 1954.
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