Methyl Donor Nutrient Intake and Incidence of Type 2 Diabetes: Results From Three Large U.S. Cohorts.

IF 14.8 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetes Care Pub Date : 2023-10-01 DOI:10.2337/dc23-0662
Caleigh M Sawicki, Danielle E Haslam, Kim V E Braun, Jean-Philippe Drouin-Chartier, Trudy Voortman, Oscar H Franco, Qi Sun, Frank B Hu, Shilpa N Bhupathiraju
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引用次数: 0

Abstract

Objective: We examined whether intake of methyl donor nutrients, including vitamins B2, B6, and B12 and folate, from foods and/or supplements is associated with type 2 diabetes risk.

Research design and methods: We included 203,644 women and men from the Nurses' Health Study (1984-2016), Nurses' Health Study 2 (1991-2017), and Health Professionals Follow-Up Study (1986-2016). Dietary data were collected every 2-4 years with use of semiquantitative food-frequency questionnaires. Cox proportional hazards models with time-varying covariates were used to evaluate associations between each nutrient and type 2 diabetes risk. We combined cohort-specific hazard ratios (HRs) using inverse variance-weighted fixed-effects meta-analyses.

Results: During 4,900,181 person-years of follow-up, we documented 19,475 incident type 2 diabetes cases. In multivariable-adjusted meta-analyses, participants in the highest quintiles of total vitamin B2 and B6 intakes had lower risk of diabetes compared with those in the lowest quintiles (HR 0.93 [95% CI 0.89, 0.98] for B2 and 0.93 [0.89, 0.97] for B6). With stratification by source, significant associations remained for B2 from food but not from supplements. Neither association for B6 from food nor association for B6 from supplements attained significance. No association was observed between total B12 intake and diabetes. However, B12 from food was marginally associated with higher diabetes risk (1.05 [1.00-1.11]) but not after additional adjustment for red meat intake (1.04 [0.99-1.10]). No evidence of association was observed between intakes of folate and diabetes.

Conclusions: The results of our study suggest that higher intake of vitamin B2 and B6, especially B2 from food sources, may be associated with a modestly lower type 2 diabetes risk.

甲基供体营养摄入与2型糖尿病发病率:来自美国三个大型队列的结果。
目的:我们研究了从食物和/或补充剂中摄入甲基供体营养素,包括维生素B2、B6、B12和叶酸是否与2型糖尿病风险有关。研究设计和方法:我们纳入了203644名来自护士健康研究(1984-2016)、护士健康研究2(1991-2017)和卫生专业人员随访研究(1986-2016)的女性和男性。每2-4年使用半定量食物频率问卷收集一次饮食数据。使用具有时变协变量的Cox比例风险模型来评估每种营养素与2型糖尿病风险之间的相关性。我们使用反向方差加权固定效应荟萃分析结合了队列特异性风险比(HR)。结果:在4900181人年的随访中,我们记录了19475例2型糖尿病病例。在多变量调整后的荟萃分析中,维生素B2和B6总摄入量最高五分位数的参与者患糖尿病的风险低于最低五分位数(B2的HR 0.93[95%CI 0.89,0.98],B6的HR 0.93[0.89,0.97])。根据来源分层,食物中的B2仍然存在显著相关性,但补充剂中的B2没有。食物中的B6和补充剂中的B6都没有显著关联。未观察到B12总摄入量与糖尿病之间的相关性。然而,食物中的B12与较高的糖尿病风险略有关联(1.05[1.00-1.11]),但在对红肉摄入量进行额外调整后没有关联(1.04[0.99-1.10])。没有观察到叶酸摄入量与糖尿病之间存在关联的证据。结论:我们的研究结果表明,摄入更多的维生素B2和B6,尤其是食物来源的B2,可能与2型糖尿病风险适度降低有关。
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来源期刊
Diabetes Care
Diabetes Care 医学-内分泌学与代谢
CiteScore
27.80
自引率
4.90%
发文量
449
审稿时长
1 months
期刊介绍: The journal's overarching mission can be captured by the simple word "Care," reflecting its commitment to enhancing patient well-being. Diabetes Care aims to support better patient care by addressing the comprehensive needs of healthcare professionals dedicated to managing diabetes. Diabetes Care serves as a valuable resource for healthcare practitioners, aiming to advance knowledge, foster research, and improve diabetes management. The journal publishes original research across various categories, including Clinical Care, Education, Nutrition, Psychosocial Research, Epidemiology, Health Services Research, Emerging Treatments and Technologies, Pathophysiology, Complications, and Cardiovascular and Metabolic Risk. Additionally, Diabetes Care features ADA statements, consensus reports, review articles, letters to the editor, and health/medical news, appealing to a diverse audience of physicians, researchers, psychologists, educators, and other healthcare professionals.
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