A historical perspective on HLA.

IF 4.1 Q2 IMMUNOLOGY
Walter Bodmer
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Abstract

The discovery of the history of the HLA system is reviewed from the earliest attempts at cancer transfers between mice, through the discovery of the mouse H-2 system on mouse red blood cells, the discovery of HLA class II and II antigens by use of sera from multiparous women, to the resolution of the HLA and H-2 functions explained by the attachment of intra cellular peptides to the HLA antigen grooves on the cell surface. The study of the associations between HLA types and diseases forms the basis for the subsequent extensive study of the genetics of human complex disease and phenotypes by GWAS (Genome Wide Association Studies).

HLA的历史观点。
本文回顾了HLA系统的发现历史,从最早的癌症在小鼠之间转移的尝试,通过小鼠红细胞上小鼠H-2系统的发现,通过使用多胎妇女的血清发现HLA II类和II类抗原,到细胞内肽附着在细胞表面HLA抗原凹槽上解释HLA和H-2功能的解决。HLA类型与疾病之间关联的研究为GWAS(全基因组关联研究)随后对人类复杂疾病和表型遗传学的广泛研究奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.00
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0.00%
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审稿时长
7 weeks
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