T1 Mapping for Differentiating of Haemorrhagic Transformation from Extravasation of Iodine Contrast Agents: A Phantom Study.

Pub Date : 2023-07-01 DOI:10.29271/jcpsp.2023.07.742

Rong Liu, Sunyu Hua, Chaogang Wei, Wu Cai, Chao Sun

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引用次数: 0

Abstract

Objective: To evaluate T1 mapping values in different concentrations of iodine and mixed blood and to simulate the application of T1 mapping in differentiating iodine contrast extravasation and haemorrhage transformation after revascularisation in acute ischemic stroke.

Study design: A phantom-based experimental study. Place and Duration of the Study: Department of Radiology, the Second Affiliated Hospital of Soochow University, China, from October 2020 to December 2021.

Methodology: Fresh blood, pure iodine, blood-iodine mixtures (75/25, 50/50, and 25/75 ratios), and diluted iodine (at a concentration of 2.1 mmol I/L) were scanned in a phantom on 3-T MR T1 mapping imaging. A total of 10 layers in the middle section of tubes were scanned. The mean value of T1 mapping and 95% confidence interval for the investigated sample compositions were calculated and compared by ANOVA.

Results: The mean values (95% CI) for fresh blood, [2/3] blood +[1/3] iodine, [1/2] blood +[1/2] iodine, [1/3] blood +[2/3] iodine, and pure iodine were 2108.69 ± 1966.68-2250.71(ms), 1991.72 ± 1763.22-2220.21(ms), 1811.62 ± 1614.79-2008.45(ms), 1624.39 ± 1442.41-1806.37(ms), 1294.68 ± 1172.92-1416.44(ms), respectively. The differences between the T1 mapping values of all compositions were significant (p <0.01), except for fresh blood and the sample consisting of 67% blood. The mean value on T1 mapping (95% CI) was 1294.68 ± 1172.92-1416.44 (ms) in the samples only with diluted iodine, which was significantly different from other investigated samples (p <0.01). The intra-class correlation coefficient between the two times drawing of radiologist A was excellent (ICC=0.913, p<0.01), and between radiologists A and B was 0.99.

Conclusion: Iodine contrast extravasation in a phantom setting might be distinguished from haemorrhagic transformation using T1 mapping.

Key words: Acute ischemic stroke, Haemorrhage transformation, Contrast extravasation, Magnetic resonance imaging, T1 mapping, 3T MRI.

查看原文

T1定位鉴别出血性转化与碘造影剂外渗:一项幻象研究。

目的:评价不同浓度碘和混合血T1测图的价值，模拟T1测图在急性缺血性脑卒中碘造影剂外渗和血运重建后出血转化鉴别中的应用。研究设计:基于幻影的实验研究。研究地点和时间:中国苏州大学第二附属医院放射科，2020年10月至2021年12月。方法:对新鲜血液、纯碘、血碘混合物(75/ 25,50 /50和25/75的比例)和稀释碘(浓度为2.1 mmol I/L)在3-T MR T1成像上进行扫描。共扫描管内中段10层。计算被调查样本组成的T1映射平均值和95%置信区间，并通过方差分析进行比较。结果:新鲜血、[2/3]血+[1/3]碘、[1/2]血+[1/2]碘、[1/3]血+[2/ 2]碘、[1/3]血+[2/3]碘、纯碘的平均值(95% CI)分别为2108.69±1966.68 ~ 2250.71(ms)、1991.72±1763.22 ~ 2220.21(ms)、1811.62±1614.79 ~ 2008.45(ms)、1624.39±1442.41 ~ 1806.37(ms)、1294.68±1172.92 ~ 1416.44(ms)。结论:碘造影剂外渗可以通过T1定位与出血转化区分开来。关键词:急性缺血性卒中，出血转化，造影剂外渗，磁共振成像，T1定位，3T MRI。

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