Pathogenesis of Zika Virus Infection.

IF 28.4 1区医学 Q1 PATHOLOGY

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 Epub Date: 2022-09-23 DOI:10.1146/annurev-pathmechdis-031521-034739

Maria I Giraldo, Maria Gonzalez-Orozco, Ricardo Rajsbaum

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引用次数: 0

Abstract

Zika virus (ZIKV) is an emerging virus from the Flaviviridae family that is transmitted to humans by mosquito vectors and represents an important health problem. Infections in pregnant women are of major concern because of potential devastating consequences during pregnancy and have been associated with microcephaly in newborns. ZIKV has a unique ability to use the host machinery to promote viral replication in a tissue-specific manner, resulting in characteristic pathological disorders. Recent studies have proposed that the host ubiquitin system acts as a major determinant of ZIKV tropism by providing the virus with an enhanced ability to enter new cells. In addition, ZIKV has developed mechanisms to evade the host immune response, thereby allowing the establishment of viral persistence and enhancing viral pathogenesis. We discuss recent reports on the mechanisms used by ZIKV to replicate efficiently, and we highlight potential new areas of research for the development of therapeutic approaches.

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寨卡病毒感染的发病机制。

寨卡病毒（ZIKV）是黄病毒科的一种新兴病毒，通过蚊子媒介传播给人类，是一个重要的健康问题。孕妇感染是一个主要问题，因为在怀孕期间可能会造成毁灭性后果，并且与新生儿小头畸形有关。ZIKV具有独特的能力，可以利用宿主机制以组织特异性的方式促进病毒复制，从而导致特征性病理疾病。最近的研究表明，宿主泛素系统通过增强病毒进入新细胞的能力，成为ZIKV向性的主要决定因素。此外，ZIKV还开发了逃避宿主免疫反应的机制，从而建立了病毒的持久性并增强了病毒的发病机制。我们讨论了最近关于ZIKV有效复制机制的报告，并强调了开发治疗方法的潜在新研究领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Pathology-Mechanisms of Disease 医学-病理学

CiteScore

62.60

自引率

0.00%

发文量

期刊介绍： The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.