The collaborative study on the genetics of alcoholism: Brain function

IF 2.4 4区 心理学 Q2 BEHAVIORAL SCIENCES
Jacquelyn L. Meyers, Sarah J. Brislin, Chella Kamarajan, Martin H. Plawecki, David Chorlian, Andrey Anohkin, Samuel Kuperman, Alison Merikangas, Gayathri Pandey, Sivan Kinreich, Ashwini Pandey, Howard J. Edenberg, Kathleen K. Bucholz, COGA Collaborators, Laura Almasy, Bernice Porjesz
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引用次数: 3

Abstract

Alcohol use disorder (AUD) and related health conditions result from a complex interaction of genetic, neural and environmental factors, with differential impacts across the lifespan. From its inception, the Collaborative Study on the Genetics of Alcoholism (COGA) has focused on the importance of brain function as it relates to the risk and consequences of alcohol use and AUD, through the examination of noninvasively recorded brain electrical activity and neuropsychological tests. COGA's sophisticated neurophysiological and neuropsychological measures, together with rich longitudinal, multi-modal family data, have allowed us to disentangle brain-related risk and resilience factors from the consequences of prolonged and heavy alcohol use in the context of genomic and social-environmental influences over the lifespan. COGA has led the field in identifying genetic variation associated with brain functioning, which has advanced the understanding of how genomic risk affects AUD and related disorders. To date, the COGA study has amassed brain function data on over 9871 participants, 7837 with data at more than one time point, and with notable diversity in terms of age (from 7 to 97), gender (52% female), and self-reported race and ethnicity (28% Black, 9% Hispanic). These data are available to the research community through several mechanisms, including directly through the NIAAA, through dbGAP, and in collaboration with COGA investigators. In this review, we provide an overview of COGA's data collection methods and specific brain function measures assessed, and showcase the utility, significance, and contributions these data have made to our understanding of AUD and related disorders, highlighting COGA research findings.

Abstract Image

关于酗酒遗传学的合作研究:大脑功能。
酒精使用障碍(AUD)和相关健康状况是遗传、神经和环境因素复杂相互作用的结果,在整个生命周期中都有不同的影响。从一开始,酒精中毒遗传学合作研究(COGA)就通过检查非侵入性记录的脑电活动和神经心理测试,关注大脑功能的重要性,因为它与饮酒和AUD的风险和后果有关。COGA复杂的神经生理学和神经心理学测量,加上丰富的纵向、多模式的家庭数据,使我们能够从基因组和社会环境对寿命的影响中,将与大脑相关的风险和恢复力因素与长期大量饮酒的后果区分开来。COGA在识别与大脑功能相关的基因变异方面处于领先地位,这促进了对基因组风险如何影响AUD和相关疾病的理解。到目前为止,COGA研究已经收集了超过9871名参与者的大脑功能数据,其中7837人在多个时间点有数据,在年龄(从7岁到97岁)、性别(52%为女性)以及自我报告的种族和民族(28%为黑人,9%为西班牙裔)方面存在显著差异。这些数据可通过多种机制提供给研究界,包括直接通过NIAA、dbGAP以及与COGA研究人员合作。在这篇综述中,我们概述了COGA的数据收集方法和评估的特定脑功能指标,并展示了这些数据对我们理解AUD和相关疾病的效用、意义和贡献,重点介绍了COGA研究结果。
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来源期刊
Genes Brain and Behavior
Genes Brain and Behavior 医学-行为科学
CiteScore
6.80
自引率
4.00%
发文量
62
审稿时长
4-8 weeks
期刊介绍: Genes, Brain and Behavior was launched in 2002 with the aim of publishing top quality research in behavioral and neural genetics in their broadest sense. The emphasis is on the analysis of the behavioral and neural phenotypes under consideration, the unifying theme being the genetic approach as a tool to increase our understanding of these phenotypes. Genes Brain and Behavior is pleased to offer the following features: 8 issues per year online submissions with first editorial decisions within 3-4 weeks and fast publication at Wiley-Blackwells High visibility through its coverage by PubMed/Medline, Current Contents and other major abstracting and indexing services Inclusion in the Wiley-Blackwell consortial license, extending readership to thousands of international libraries and institutions A large and varied editorial board comprising of international specialists.
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