Evaluation of the Role of Tumor-Infiltrating Lymphocytes and CD8+ Cytotoxic Lymphocytes in the Survival of Patients with Breast Cancer.

Q3 Medicine
Shahram Shojaei, Mozaffar Aznab, Amirmasoud Rahimi, Seyed Mojtaba Ahmadi, Kumars Eslampia, Arash Golpazir, Masoud Iravani
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Abstract

Background: This study aimed to evaluate the significance of tumor-infiltrating lymphocyte (TIL) and the number of CD8+ T cells in breast cancer and their relationship with the other clinicopathological factors, and overall survival (OS) was investigated. Materials and Methods: The studied samples were breast cancer patients (2005-2017) referring to the medical oncology departments for treatment. Pathologic samples of breast cancer patients were evaluated in terms of TIL and positive immunohistochemical staining for CD8 cytotoxic cells. Results: 299 patients were entered into the study, three were male and 296 female. Their mean follow-up period was 61 months. Statistical findings indicated that lymph involvement is more accompanied by low TIL within the tumor (0.011). Correlations were observed between the estrogen, progesterone receptors, P53 state, and TIL, which were significant by P-value<0.049, P-value=0.024, P-value =0.002, respectively. With any Ki67 value, the number of patients with less than 30% TIL was more considerable than the other two groups with lymphocyte cut-off of 30-50% and more than 50%. Comparison of the OS of patients with positive and negative CD8 cytotoxic lymphocytes in 45 patients with lymphocyte infiltration of equal or more than 40% showed that the OS results were in favor of patients with CD8+ cytotoxic lymphocyte (0.022). Out of 299 patients, 17 died. Conclusion: Our findings showed that in cases of CD8+ cytotoxic lymphocytes in tumors, the OS of the patients will be enhanced which can act as an independent factor.

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肿瘤浸润淋巴细胞和CD8+细胞毒性淋巴细胞在乳腺癌患者生存中的作用
背景:本研究旨在探讨肿瘤浸润淋巴细胞(TIL)和CD8+ T细胞数量在乳腺癌中的意义及其与其他临床病理因素的关系,并探讨其与总生存率(OS)的关系。材料与方法:研究样本为2005-2017年在内科肿瘤科就诊的乳腺癌患者。对乳腺癌患者病理标本进行TIL和CD8细胞毒性细胞免疫组化染色阳性评价。结果:299例患者入组,其中男性3例,女性296例。平均随访61个月。统计结果显示,淋巴结受累更多地伴有肿瘤内低TIL(0.011)。雌激素、孕激素受体、P53状态与TIL之间存在p值显著相关。结论:我们的研究结果表明,肿瘤中CD8+细胞毒性淋巴细胞的存在会提高患者的OS,这可能是一个独立的因素。
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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
32
审稿时长
12 weeks
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