Fetal High-Risk APOL1 Genotype Increases Risk for Small for Gestational Age in Term Infants Affected by Preeclampsia.

IF 2.6 3区医学 Q1 PEDIATRICS

Neonatology Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI:10.1159/000529850

Timur Azhibekov, Razaq Durodoye, Anna K Miller, Claire L Simpson, Robert L Davis, Scott M Williams, Leslie A Bruggeman

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引用次数: 0

Abstract

Background: Hypertensive disorders of pregnancy cause fetal growth restriction and increased maternal morbidity and mortality, especially in women of African ancestry. Recently, preeclampsia risk was associated with polymorphisms in the apolipoprotein L1 (APOL1) gene in women of African ancestry.

Objectives: We assessed APOL1 genotype effects on pregnancies with and without preeclampsia.

Method: We conducted an unmatched case-control study of 1,358 mother-infant pairs from two independent cohorts of black women.

Results: Term preeclampsia cases with high-risk APOL1 genotypes were more likely to be small for gestational age compared to APOL1 low-risk term cases (odds ratio [OR] 2.8) and APOL1 high-risk controls (OR 5.5). Among preterm pregnancies, fetal APOL1 genotype was associated with preeclampsia.

Conclusions: Fetal APOL1 genotype was associated with preeclampsia in preterm infants and with altered fetal growth in term infants. This may indicate APOL1 genotype impacts a spectrum of pregnancy complications mediated by a common pathophysiological event of placental insufficiency.

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胎儿高危型APOL1基因型增加先兆子痫足月婴儿的小孕龄风险。

背景：妊娠期高血压疾病会导致胎儿生长受限，并增加产妇的发病率和死亡率，尤其是非洲血统的妇女。最近，非洲血统女性的载脂蛋白L1（APOL1）基因多态性与先兆子痫风险相关。目的：我们评估了APOL1基因型对先兆子痫和非先兆子痫妊娠的影响。方法：我们对来自两个独立的黑人女性队列的1358对母婴进行了一项不匹配的病例对照研究。结果：与APOL1低风险足月病例（比值比[OR]2.8）和APOL1高风险对照组（比值比5.5）相比，具有高危APOL1基因型的足月先兆子痫患者的胎龄更小。结论：胎儿APOL1基因型与早产儿先兆子痫和足月儿胎儿生长发育异常有关。这可能表明APOL1基因型影响一系列由胎盘功能不全常见病理生理事件介导的妊娠并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neonatology 医学-小儿科

CiteScore

0.60

自引率

4.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomized trials, observational studies and epidemiology. Basic science research covers molecular biology, molecular genetics, physiology, biochemistry and pharmacology in fetal and neonatal life. In addition to the classic features the journal accepts papers for the sections Research Briefings and Sources of Neonatal Medicine (historical pieces). Papers reporting results of animal studies should be based upon hypotheses that relate to developmental processes or disorders in the human fetus or neonate.