Quality Consistency of Herbal Products: Chemical Evaluation.

Q1 Medicine
Ahmed Osman, Amar G Chittiboyina, Bharathi Avula, Zulfiqar Ali, Sebastian J Adams, Ikhlas A Khan
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Abstract

The widespread utility of herbal products has been rising considerably worldwide, including both developed and developing countries, leading to the rapid growth of their availability in the United States and globally. This substantial increase in consumption of herbal products has witnessed the emergence of adverse effects upon oral administration of certain of these products, and thus has raised safety concerns. The adverse effects caused by the consumption of certain botanical medicines occur primarily as a result of the poor quality of plant raw materials or the finished products, which inherently may affect safety and/or efficacy. The poor quality of some herbal products can be attributed to a lack of proper quality assurance and quality control. A high demand for herbal products that surpasses production, combined with a desire for maximizing profits, along with a lack of rigorous quality control within some manufacturing facilities have led to the emergence of quality inconsistencies. The underlying causes for this involve the misidentification of plant species, or their substitution, adulteration, or contamination with harmful ingredients. Analytical assessments have revealed there to be frequent and significant compositional variations between marketed herbal products. The inconsistency of the quality of herbal products can be ascribed essentially to the inconsistency of the botanical raw material quality used to manufacture the products. Thus, the quality assurance and the quality control of the botanical raw materials is may contribute significantly to improving the quality and consistency of the quality of the end products. The current chapter focuses on the chemical evaluation of quality and consistency of herbal products, including botanical dietary supplements. Different techniques, instruments, applications, and methods used in identifying, quantifying, and generating chemical fingerprints and chemical profiles of the ingredients of the herbal products will be described. The strengths and weaknesses of the various techniques available will be addressed. Limitations of the other approaches including morphological or microscopic analysis and DNA-based analysis will be presented.

草药产品的质量一致性:化学评价。
在世界范围内,包括发达国家和发展中国家,草药产品的广泛应用已经大大增加,导致它们在美国和全球的可用性迅速增长。草药产品消费量的大幅增加已经见证了某些此类产品口服后出现的不良反应,从而引起了安全问题。食用某些植物性药物造成的不良反应主要是由于植物原料或成品质量差,这本质上可能影响安全性和/或有效性。一些草药产品的质量差可归因于缺乏适当的质量保证和质量控制。对草药产品的高需求超过了生产,加上对利润最大化的渴望,以及一些生产设施缺乏严格的质量控制,导致了质量不一致的出现。造成这种情况的根本原因包括植物物种的错误识别,或它们的替代、掺假或被有害成分污染。分析评估显示,在已上市的草药产品之间存在频繁和显著的成分差异。草药产品质量的不一致主要归因于用于制造产品的植物原料质量的不一致。因此,植物原料的质量保证和质量控制对提高最终产品的质量和一致性具有重要意义。本章的重点是草药产品的质量和一致性的化学评价,包括植物性膳食补充剂。将描述用于识别、量化和生成草药产品成分的化学指纹和化学特征的不同技术、仪器、应用和方法。将讨论各种可用技术的优缺点。其他方法的局限性,包括形态学或显微分析和基于dna的分析将被提出。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
4.40
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0.00%
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0
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