CANCER-ASSOCIATED ADIPOCYTES AND PROGNOSTIC VALUE OF PREOPERATIVE NEUTROPHIL-LYMPHOCYTE RATIO IN GASTRIC CANCER.

Q3 Medicine

Experimental oncology Pub Date : 2023-06-26 DOI:10.15407/exp-oncology.2023.01.088

L Bubnovskaya, I Ganusevich, S Merentsev, D Osinsky

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Abstract

Background: The neutrophil-to-lymphocyte ratio (NLR) turned out to be a routinely available marker capable to reflect the systemic inflammatory response created by a tumor. Gastric cancer (GC) grows in the anatomical vicinity of adipose tissue, which is also associated with low-grade inflammation.

Aim: To investigate the usefulness of the combined use of preoperative NLR and density of intratumoral cancer-associated adipocytes (CAAs) for predicting the disease outcome in GC patients.

Materials and methods: A total of 151 patients with GC were eligible for retrospective analysis between 2009 and 2015.NLR preoperative values were calculated. Perilipin expression in tumor tissue was examined immunohistochemically.

Results: Low preoperative NLR is the most reliable prognostic factor for the favorable outcome for patients with low density of intratumoral CAAs. Patients with a high density of CCAs are at high risk of lethal outcomes independently of the value of preoperative NLR.

Conclusion: The results have clearly shown an association between preoperative NLR and the density of CAAs in the primary tumor of GC patients. The prognostic value of NLR is essentially modified by means of the individual density of intratumoral CAAs in GC patients.The elevated NLR could be of significant predictive potential for a negative prognosis for patients with tumors characterized by the high density of CAAs independently of BMI.

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胃癌相关脂肪细胞及术前中性粒细胞/淋巴细胞比值的预后价值。

背景:中性粒细胞与淋巴细胞比率(NLR)是一种常规可用的标志物，能够反映肿瘤引起的全身炎症反应。胃癌(GC)生长在脂肪组织的解剖附近，这也与低度炎症有关。目的:探讨术前NLR和肿瘤内肿瘤相关脂肪细胞(CAAs)密度对胃癌患者预后的预测价值。材料和方法:2009 - 2015年共有151例GC患者入选回顾性分析。计算NLR术前值。免疫组织化学检测肿瘤组织中Perilipin的表达。结果:术前低NLR是低密度瘤内caa患者预后最可靠的预后因素。与术前NLR值无关，高密度cca患者的死亡风险较高。结论:本研究结果清楚地显示了胃癌患者原发肿瘤中CAAs密度与术前NLR的相关性。NLR的预后价值主要取决于胃癌患者肿瘤内CAAs的个体密度。对于以caa高密度为特征的肿瘤患者，NLR升高可能具有显著的预测预后的潜力，而不依赖于BMI。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.