Impact of patient characteristic factors on the dynamics of liver glucose metabolism: Evaluation of multiparametric imaging with dynamic whole-body 18F-fluorodeoxyglucose-positron emission tomography

IF 5.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes, Obesity & Metabolism Pub Date : 2023-08-17 DOI:10.1111/dom.15247

Kai Tonda MD, Yu Iwabuchi MD, Tohru Shiga MD, Yoshiki Owaki RT, Arashi Fujita RT, Takehiro Nakahara MD, Ryosuke Sakurai MD, Atsushi Shimizu MD, Yoshitake Yamada MD, Masahiro Okada MD, Masahiro Jinzaki MD

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Abstract

Aims

To assess the impact of various patient characteristics on the dynamics of liver glucose metabolism using automated multiparametric imaging with whole-body dynamic ¹⁸F-fluorodeoxyglucose (FDG)-positron emission tomography (PET).

Materials and Methods

We retrospectively enrolled 540 patients who underwent whole-body dynamic FDG-PET. Three quantitative indices representing hepatic glucose metabolism [mean standardized uptake value normalized by lean body mass (SULmean), metabolic glucose rate (kinetic index) and distribution volume (DV)] were measured from multiparametric PET images produced automatically based on the Patlak plot model. Patient characteristics including age, sex, body mass index, fasting time, blood glucose level, and the presence of diabetes mellitus (DM) or hepatic steatosis (HS) were collected. We examined the correlations between the characteristic factors and three quantitative indices using multiple regression analysis.

Results

The success rate of kinetic analysis using multiparametric PET imaging was 93.3% (504/540). Hepatic SULmean was significantly correlated with age (p < .001), sex (p < .001) and blood glucose level (p = .002). DV was significantly correlated with age (p = .033), sex (p < .001), body mass index (p = .002), fasting time (p = .043) and the presence of HS (p = .002). The kinetic index was significantly correlated with age (p < .001) and sex (p = .004). In the comparison of the healthy, DM and HS groups, patients with DM had a significantly increased SULmean, whereas patients with HS had a significantly decreased DV.

Conclusions

Our results showed that liver glucose metabolism was influenced by various patient characteristic factors. Multiparametric FDG-PET imaging can be used to analyse the kinetics of liver glucose metabolism in routine clinical practice.

Abstract Image

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患者特征因素对肝糖代谢动力学的影响:动态全身18f -氟脱氧葡萄糖-正电子发射断层多参数成像的评价

目的利用全自动多参数全身动态18f -氟脱氧葡萄糖(FDG)-正电子发射断层扫描(PET)技术评估不同患者特征对肝糖代谢动力学的影响。材料和方法我们回顾性地纳入540例接受全身动态FDG-PET治疗的患者。从基于Patlak图模型自动生成的多参数PET图像中测量代表肝脏糖代谢的三个定量指标[以瘦体重(SULmean)归一化的平均标准化摄取值(mean)，代谢葡萄糖率(kinetic index)和分布体积(DV)]。收集患者的年龄、性别、体重指数、禁食时间、血糖水平、有无糖尿病(DM)或肝脂肪变性(HS)等特征。采用多元回归分析方法对特征因子与三个定量指标之间的相关性进行了检验。结果多参数PET成像动力学分析成功率为93.3%(504/540)。肝SULmean与年龄(p < .001)、性别(p < .001)、血糖水平(p = .002)显著相关。DV与年龄(p = 0.033)、性别(p < 0.001)、体重指数(p = 0.002)、禁食时间(p = 0.043)和HS的存在(p = 0.002)显著相关。动力学指数与年龄(p < .001)和性别(p = .004)显著相关。在健康组、糖尿病组和HS组的比较中，DM组患者的SULmean显著增加，而HS组患者的DV显著降低。结论肝脏糖代谢受多种患者特征因素的影响。多参数FDG-PET成像可用于分析肝脏糖代谢动力学。

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来源期刊

Diabetes, Obesity & Metabolism 医学-内分泌学与代谢

CiteScore

10.90

自引率

6.90%

发文量

319

审稿时长

3-8 weeks

期刊介绍： Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.