Multiple Sensory Impairments in Relation to Cognitive Function: Two Nationwide Cross-sectional Studies.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Current Alzheimer research Pub Date : 2023-01-01 DOI:10.2174/1567205020666230816090903

Binghan Wang, Hui Chen, Jie Shen, Wansi Zhong, Yan Zheng, Min Lou, Lusha Tong, Changzheng Yuan

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Abstract

Introduction: Sensory impairments (SIs, including visual, hearing, olfactory, and taste impairments) have been individually associated with age-related cognitive function. Little is known regarding their combined associations with cognitive function.

Methods: We included 2,931 participants (mean age of 69.1 years) from the National Health and Nutrition Examination Survey (NHANES, 2011-2014) and 10,785 participants (mean age of 70.2 years) from the National Health Interview Survey (NHIS, 2021). Status of visual, hearing, olfactory, and taste functions were self-reported in structured questionnaires. In NHANES, cognitive function was objectively measured by a battery of tests, including memory, verbal fluency, and processing speed. NHIS participants answered a single question about subjective cognitive complaints (SCC). We used regression models to assess the relation of the total number and the individual sensory impairments to z-scores of cognitive domains (linear regression) in NHANES and to SCC (logistic regression) in NHIS.

Results: A larger number of SI was related to poorer domain-specific cognitive function (all Ptrend <0.05), including memory (beta _{each additional SI} = -0.12, 95% confidence interval: -0.17 to -0.08), verbal fluency (-0.05, -0.10 to -0.01), and processing speed (-0.13, -0.16 to -0.09). In NHIS, each additional SI was related to 96% higher odds of SCC. We also observed independent associations of sensory impairments (except olfactory impairment) with specific cognitive domains. In addition, each individual SI was associated with higher odds of SCC (the odds ratios ranged from 1.30 to 1.78).

Conclusion: A larger number of SI was related to worse cognitive function and higher odds of SCC.

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多种感觉障碍与认知功能的关系：两项全国性的横断面研究。

引言：感觉障碍（包括视觉、听觉、嗅觉和味觉障碍）与年龄相关的认知功能单独相关。关于它们与认知功能的结合，目前知之甚少。方法：我们纳入了来自国家健康和营养检查调查（NHANES，2011-2014）的2931名参与者（平均年龄69.1岁）和来自国家健康访谈调查（NHIS，2021）的10785名参与者（均值70.2岁）。视觉、听觉、嗅觉和味觉功能的状态在结构化问卷中自我报告。在NHANES中，认知功能是通过一系列测试来客观衡量的，包括记忆力、语言流利性和处理速度。NHIS参与者回答了一个关于主观认知抱怨（SCC）的问题。我们使用回归模型来评估总数和个体感觉障碍与NHANES认知领域z评分（线性回归）和NHIS SCC（逻辑回归）的关系，言语流利度（-0.05，-0.10至-0.01）和处理速度（-0.13，-0.16至-0.09）。在NHIS中，每增加一个SI，SCC的几率就高出96%。我们还观察到感觉障碍（嗅觉障碍除外）与特定认知领域的独立关联。此外，每个个体的SI都与较高的SCC发生几率相关（比值比为1.30至1.78）。结论：大量的SI与较差的认知功能和较高的SCC发病几率有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Alzheimer research 医学-神经科学

CiteScore

4.00

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.