Waiting times in a branching process model of colorectal cancer initiation

IF 1.2 4区生物学 Q4 ECOLOGY

Theoretical Population Biology Pub Date : 2023-06-01 DOI:10.1016/j.tpb.2023.04.001

Ruibo Zhang, Obinna A. Ukogu, Ivana Bozic

引用次数: 0

Abstract

We study a multi-stage model for the development of colorectal cancer from initially healthy tissue. The model incorporates a complex sequence of driver gene alterations, some of which result in immediate growth advantage, while others have initially neutral effects. We derive analytic estimates for the sizes of premalignant subpopulations, and use these results to compute the waiting times to premalignant and malignant genotypes. This work contributes to the quantitative understanding of colorectal tumor evolution and the lifetime risk of colorectal cancer.

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结直肠癌起始分支过程模型中的等待时间

我们从最初的健康组织中研究了结直肠癌癌症发展的多阶段模型。该模型包含了一系列复杂的驱动基因改变，其中一些改变会立即产生生长优势，而另一些则最初具有中性影响。我们推导了癌前亚群大小的分析估计，并使用这些结果来计算癌前和恶性基因型的等待时间。这项工作有助于定量了解结直肠癌的演变和结直肠癌癌症的终生风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Theoretical Population Biology 生物-进化生物学

CiteScore

2.50

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： An interdisciplinary journal, Theoretical Population Biology presents articles on theoretical aspects of the biology of populations, particularly in the areas of demography, ecology, epidemiology, evolution, and genetics. Emphasis is on the development of mathematical theory and models that enhance the understanding of biological phenomena. Articles highlight the motivation and significance of the work for advancing progress in biology, relying on a substantial mathematical effort to obtain biological insight. The journal also presents empirical results and computational and statistical methods directly impinging on theoretical problems in population biology.