The Peritumoral CD8 + /FOXP3 + Cell Ratio Has Prognostic Value in Triple-negative Breast Cancer.

IF 1.3 4区 医学 Q3 ANATOMY & MORPHOLOGY
Rana Aldrees, Gene P Siegal, Shi Wei
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引用次数: 0

Abstract

Compelling data has demonstrated the prognostic significance of tumor-infiltrating lymphocytes (TILs) in triple-negative breast cancer (TNBC), a subtype generally associated with a poor clinical outcome but highly heterogeneous in nature. There have been limited studies investigating the importance of subsets of T cells in TILs. Further, the significance of intratumoral versus peritumoral TILs remains controversial. We examined the prognostic value of tumor-associated CD8 + cytotoxic T cells and FOXP3 + regulatory T cells in 35 chemotherapy-naive TNBC cases with a tumor-host interface in the tissue sections. The CD8 + and FOXP3 + cell count was expressed by immunoreactive cells per high-power field in an average of 10 high-power fields. There was a wide range of CD8 + and FOXP3 + T cells within the peritumoral and intratumoral stroma. Both CD8 + and FOXP3 + TILs were significantly higher at the former location as compared with the latter ( P <0.0001 and 0.003, respectively). The numbers of CD8 + and FOXP3 + T cells, either within peritumoral or intratumoral stroma, were not significantly associated with distant relapse-free or disease-specific survival. However, the peritumoral CD8 + /FOXP3 + ratio of TILs was significantly associated with prolonged relapse-free survival ( P =0.04) and disease-specific survival ( P =0.02). This association was not observed with the CD8 + /FOXP3 + ratio of intratumoral TILs. These observations suggest that the immunologic balance in the tumor microenvironment might determine antitumor immunity. Further, the peritumoral TILs appear to play a more important role in the progression of TNBC when compared with the intratumoral TILs, thus reaffirming the necessity of revisiting the method for the assessment of TILs.

瘤周CD8+/FOXP3+细胞比率对癌症三阴性具有预后价值。
令人信服的数据证明了肿瘤浸润性淋巴细胞(TIL)在癌症(TNBC)三阴性中的预后意义,这是一种通常与较差的临床结果相关但本质上高度异质性的亚型。研究T细胞亚群在TIL中的重要性的研究有限。此外,肿瘤内TIL与肿瘤周围TIL的意义仍然存在争议。我们在35例组织切片中存在肿瘤-宿主界面的化疗初期TNBC病例中检测了肿瘤相关CD8+细胞毒性T细胞和FOXP3+调节性T细胞的预后价值。CD8+和FOXP3+细胞计数由免疫反应细胞在平均10个高功率场中每高功率场表达。肿瘤周围和肿瘤内基质中存在广泛的CD8+和FOXP3+T细胞。CD8+和FOXP3+TIL在前者显著高于后者(P
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来源期刊
Applied Immunohistochemistry & Molecular Morphology
Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY
CiteScore
3.20
自引率
0.00%
发文量
153
期刊介绍: ​Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology​.
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