An analysis of the relationship of blood pressure and its variability with residual kidney function loss in hemodialysis patients.

IF 1.1 4区医学 Q3 UROLOGY & NEPHROLOGY

Clinical nephrology Pub Date : 2023-09-01 DOI:10.5414/CN111010

Feiyan Li, Xu He, Yongchao Yang

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引用次数: 0

Abstract

Aims: This study aims to investigate the relationship of blood pressure (BP) and systolic BP (SBP) variability with residual kidney function (RKF) loss in hemodialysis (HD) patients.

Materials and methods: The demographic and clinical information and data on RKF loss events in HD patients were collected. The baseline characteristics of the patients were compared among groups according to pre- and postdialysis SBP (< 120, 120 - 139, 140 - 159, and ≥ 160 mmHg) and diastolic BP (DBP) (< 80, 80 - 89, 90 - 99, and ≥ 1 00 mmHg). Participants were divided into two groups based on the mean intradialytic and interdialytic SBP variability. Kaplan-Meier analysis and Cox regression analysis were used to evaluate the risk of RKF loss.

Results: A total of 157 participants with an average HD vintage of 35.97 months were included. The group with the lowest predialysis SBP showed the longest duration of residual urine. However, Kaplan-Meier analysis and Cox regression analysis indicated that BP and SBP variability were not independent risk factors for RKF loss. Higher serum albumin levels showed protective effects against RKF loss, and diabetes mellitus (DM) and higher serum calcium were the independent risk factors for RKF loss.

Conclusion: BP and SBP variability were not independent risk factors for RKF loss in HD patients. DM, serum albumin, and calcium were independent factors related to RKF loss.

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血透患者血压及其变异性与残余肾功能丧失的关系分析。

目的:本研究旨在探讨血液透析(HD)患者血压(BP)和收缩压(SBP)变异性与残余肾功能(RKF)损失的关系。材料与方法:收集HD患者RKF丢失事件的人口学、临床信息和数据。根据透析前和透析后的收缩压(< 120、120 - 139、140 - 159和≥160 mmHg)和舒张压(DBP)(< 80、80 - 89、90 - 99和≥100 mmHg)比较各组患者的基线特征。参与者根据平均透析期和透析期收缩压变异性分为两组。采用Kaplan-Meier分析和Cox回归分析评价RKF丧失的风险。结果:共纳入157例患者，平均年龄为35.97个月。透析前收缩压最低组残尿持续时间最长。然而，Kaplan-Meier分析和Cox回归分析表明，血压和收缩压变异性不是RKF丧失的独立危险因素。较高的血清白蛋白水平对RKF丧失具有保护作用，糖尿病(DM)和高血钙是RKF丧失的独立危险因素。结论:血压和收缩压变异性不是HD患者RKF丧失的独立危险因素。DM、血清白蛋白和钙是与RKF损失相关的独立因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nephrology 医学-泌尿学与肾脏学

CiteScore

2.10

自引率

9.10%

发文量

138

审稿时长

4-8 weeks

期刊介绍： Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.