Subchorionic Hematoma Volume Measured by Virtual Organ Computer-Aided Analysis in the Prediction of First-Trimester Pregnancy Outcome.

IF 0.7 4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Chaoli Xu, Wenrong Wang, Bin Yang, Minmin Zhu
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Abstract

Abstract: This study aimed to assess the association of subchorionic hematoma (SCH) size measured by virtual organ computer-aided analysis (VOCAL) with the first-trimester pregnancy outcome. A total of 139 first-trimester pregnancies from 6 to 12 weeks of gestational age with SCH were included. The circumference, area, and volume of the SCH (Cs, As, and 3DVs) and gestational sac (Cg, Ag, and 3DVg) were automatically calculated by VOCAL. Interobserver agreement was assessed with the intraclass correlation coefficient and Bland-Altman plot. Odds ratios for the clinical and ultrasound characteristics of adverse pregnancy outcomes were estimated by univariate or multivariable logistic regression. There was high interobserver agreement in VOCAL measurements of the SCH and gestational sac (intraclass correlation coefficients, >0.900). By univariate regression analysis, women with adverse pregnancy outcomes were more likely to have vaginal bleeding, a larger As and 3DVs, and higher Cs/Cg, As/Ag, and 3DVs/3DVg ratios (all P < 0.05). In the multivariable regression analysis, a higher 3DVs/3DVg ratio of SCH (odds ratio, 1.034; 95% confidence interval [CI], 1.015-1.053; P = 0.000) and vaginal heavy bleeding had a significant positive relationship with the risk of adverse pregnancy outcomes (odds ratio, 7.846; 95% CI, 1.104-55.737; P = 0.039) remained associated with an increased risk of adverse pregnancy outcomes. With 11.87% as the cutoff, the receiver operating characteristic curve yielded a good predictive performance (area under the curve, 0.713) and high sensitivity (91.18%). The measurements of SCH by VOCAL provide high reliability for estimating the total hematoma burden in first-trimester pregnant patients. A greater volume proportion (3DVs/3DVg) of SCH worsens the pregnancy outcome, and a greater risk of adverse pregnancy outcome also associated with the severity of vaginal bleeding.

虚拟器官计算机辅助分析测定绒毛膜下血肿体积预测早期妊娠结局。
摘要:本研究旨在评估虚拟器官计算机辅助分析(VOCAL)测量的绒毛膜下血肿(SCH)大小与妊娠早期结局的关系。共纳入139例6 ~ 12周孕早期妊娠SCH患者。通过VOCAL自动计算SCH (Cs、As、3DVs)和孕囊(Cg、Ag、3DVg)的周长、面积、体积。用类内相关系数和Bland-Altman图评估观察者间一致性。通过单变量或多变量logistic回归估计不良妊娠结局的临床和超声特征的优势比。在超声测量SCH和孕囊时,观察者之间的一致性很高(类内相关系数,>0.900)。单因素回归分析发现,妊娠结局不良的女性阴道出血、a、3DVs较高,Cs/Cg、As/Ag、3DVs/3DVg比值较高(P < 0.05)。在多变量回归分析中,SCH的3DVs/3DVg比值较高(优势比,1.034;95%置信区间[CI], 1.015-1.053;P = 0.000)、阴道大出血与不良妊娠结局风险呈正相关(优势比为7.846;95% ci, 1.104-55.737;P = 0.039)仍然与不良妊娠结局的风险增加相关。以11.87%为截止值,受试者工作特性曲线具有良好的预测性能(曲线下面积为0.713)和较高的灵敏度(91.18%)。通过VOCAL测量SCH为估计妊娠早期患者的总血肿负担提供了高可靠性。更大的SCH体积比例(3DVs/3DVg)使妊娠结局恶化,并且阴道出血的严重程度也与更大的不良妊娠结局风险相关。
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来源期刊
Ultrasound Quarterly
Ultrasound Quarterly RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.50
自引率
7.70%
发文量
105
审稿时长
>12 weeks
期刊介绍: Ultrasound Quarterly provides coverage of the newest, most sophisticated ultrasound techniques as well as in-depth analysis of important developments in this dynamic field. The journal publishes reviews of a wide variety of topics including trans-vaginal ultrasonography, detection of fetal anomalies, color Doppler flow imaging, pediatric ultrasonography, and breast sonography. Official Journal of the Society of Radiologists in Ultrasound
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