Effects of Exercise on Testosterone and Implications of Drug Abuse: A Review.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropharmacology Pub Date : 2023-05-01 DOI:10.1097/WNF.0000000000000546

Brendan Perreault, Nikki Hammond, Panayotis K Thanos

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引用次数: 0

Abstract

Objective: Research points to exercise having a positive effect in fighting relapse and use of drugs of abuse. Through conducting this research, differences have been observed in the effects of exercise on drug abuse between sexes. Many of the studies found that exercise tends to cause a more profound effect in blocking drug relapse or reinstatement in males when compared with females.

Methods: Our hypothesis is that these differences in response to drugs of abuse after an exercise regimen could in part be attributed to variations in testosterone levels between males and females.

Results: Testosterone has been shown to have a modulatory impact on the dopaminergic activity in the brain, causing an effect on the brain's response to drugs of abuse. Exercise has demonstrated a causal effect on increasing testosterone levels in males, whereas drugs of abuse decrease testosterone levels in males.

Conclusions: Thus, exercise raising testosterone levels in males helps to decrease the dopaminergic response in the brain to drugs of abuse causing attenuation to drugs. To find sex-specific exercise treatments for drugs of abuse, it is important to continue researching exercise's efficacy against drugs of abuse.

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运动对睾酮的影响及药物滥用的影响:综述。

目的:研究指出运动对对抗药物滥用的复吸和使用有积极作用。通过这项研究，我们观察到运动对药物滥用的影响存在性别差异。许多研究发现，与女性相比，运动在阻止男性药物复发或恢复方面往往会产生更深远的影响。方法:我们的假设是，运动后对药物滥用反应的差异可能部分归因于男性和女性之间睾酮水平的差异。结果:睾酮已被证明对大脑中的多巴胺能活动有调节作用，对大脑对滥用药物的反应产生影响。运动对男性睾酮水平的增加有因果关系，而滥用药物则会降低男性睾酮水平。结论:因此，运动提高男性睾丸激素水平有助于减少大脑对药物滥用的多巴胺能反应，导致药物衰减。为了找到针对滥用药物的针对性别的运动治疗方法，继续研究运动对滥用药物的疗效是很重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropharmacology 医学-临床神经学

CiteScore

1.20

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.