Morphological changes and Mitochondrial alterations on Cardiomyocytes exposed to Fluoride.

IF 0.4 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Puerto Rico Health Sciences Journal Pub Date : 2023-06-01

Areli Limon-Rojas, Amaury Pozos-Guillén, Roberto Salgado-Delgado, Margarita Rodríguez Y Domínguez, Diana María Escobar-García

引用次数: 0

Abstract

Objective: To evaluate the morphological changes of cardiomyocytes exposed to different sodium fluoride (NaF) concentrations, as well as to evaluate the behavior of the mitochondria.

Methods: Rat H9c2 cardiomyocytes were exposed to NaF at concentrations of 0.5 to 5 mmol/L. The morphology and number of mitochondria in these cells were monitored, and the calcium ion (Ca2+) concentration was determined.

Results: Morphological changes were evident in the cells treated with different NaF concentrations, and both the number of mitochondria and the Ca2+ concentration decreased in a dose-dependent manner.

Conclusion: Sodium fluoride induced morphological damage in cardiomyocytes, decreases the Ca2+ concentration and mitochondrial number.

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氟化物对心肌细胞形态和线粒体的影响。

目的:探讨不同浓度氟化钠(NaF)对心肌细胞形态的影响及线粒体的行为。方法:大鼠H9c2心肌细胞暴露于浓度为0.5 ~ 5 mmol/L的NaF。监测这些细胞的线粒体形态和数量，并测定钙离子(Ca2+)浓度。结果:不同NaF浓度处理的细胞形态变化明显，线粒体数量和Ca2+浓度均呈剂量依赖性下降。结论:氟化钠可引起心肌细胞形态损伤，降低心肌细胞Ca2+浓度和线粒体数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Puerto Rico Health Sciences Journal PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Puerto Rico Health Sciences Journal (PRHSJ) is the scientific journal of the University of Puerto Rico Medical Sciences Campus. It was founded in 1982 as a vehicle for the publication of reports on scientific research conducted in-campus, Puerto Rico and abroad. All published work is original and peer-reviewed. The PRHSJ is included in PubMed/Medline, SCOPUS, Latindex, EBSCO, SHERPA/RoMEO, Science Citation Index Expanded (SciSearch®) and Journal Citation Reports/Science Edition. All papers are published both online and in hard copy. From its beginning, the PRHSJ is being published regularly four times a year. The scope of the journal includes a range of medical, dental, public health, pharmaceutical and biosocial sciences research. The journal publishes full-length articles, brief reports, special articles, reviews, editorials, case reports, clinical images, and letters arising from published material.