Allelic variation within the major APOE CpG island affects its methylation in the brain of targeted replacement mice expressing human APOE

IF 2.6 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms Pub Date : 2023-09-01 DOI:10.1016/j.bbagrm.2023.194942

Johanna Rueter, Gerald Rimbach, Patricia Huebbe

引用次数: 0

Abstract

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The number of cytosine-phosphate-guanine (CpG) sites differs due to sequence variation in the human apolipoprotein E (APOE) gene.
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APOE DNA methylation is allele-dependently altered corresponding to the total number of CpG pairs in the brain of APOE targeted replacement mice (APOE εpsilon 4 > εpsilon 3 > εpsilon 2).
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Binding of the methyl-CpG binding protein 2 to genomic APOE was in trend less pronounced in the brain of APOE4 mice.

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主要APOE CpG岛内的等位基因变异影响其在表达人类APOE的靶向替代小鼠大脑中的甲基化

•由于人类载脂蛋白E（APOE）基因的序列变化，胞嘧啶磷酸鸟嘌呤（CpG）位点的数量不同。•APOE DNA甲基化是等位基因依赖性改变的，对应于APOE靶向替代小鼠大脑中CpG对的总数（APOEεpsilon 4>；εpsilon 3>；βpsilon 2）。•甲基CpG结合蛋白2与基因组APOE的结合在APOE4小鼠的大脑中呈不太明显的趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

44 days

期刊介绍： BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.